Effects Of Taohechengqitang On Gene Expression Of MMP-2 And TIMP-2 In Artery Vessels Of Experimental Xuxuezheng Rats

Objective To investigate the effects of Taohechengqitang(THCQT) on the gene expression of Matrix Metalloproteinase-2(MMP-2) and Tissue Inhibitor of Metalloproteinase-2(TIMP-2)in artery vessel of experimental Xuxuezheng rats.Methods The model of Xuxuezheng was established by Escherichia Coli endotoxin.Half quantitative reverse transcription polymerase chain reaction(RT-PCR) was used to detect MMP-2 and TIMP-2 gene expression in artery vessel.The changes of gene expression of MMP-2 and TIMP-2 in artery vessels in each group were analyzed.Results MMP-2 gene expression levels in the model group were significantly higher than those of control group(P＜0.01),and TIMP-2 gene expression levels were significantly lower (P＜0.01).While compared with model group,MMP-2 gene expression levels in the THCQT group were lower(P＜0.01),and TIMP-2 gene expression levels were higher(P＜0.01).Conclusion THCQT can change the gene expression of MMP-2 and TIMP-2 in artery vessels of experimental Xuxuezheng rats,which may account for the effects of THCQT.