Effect Of Epidermal Growth Factor In Patients Of Cerebral Trauma Associated Fracture On Fracture Healing

Objctive To analyze the relationship between the concentration of EGF and fracture healing after cerebral trauma through mensurating the concentration of EGF in the group of cerebral trauma associated fracture and contrasting with the group of pure cerebral trauma,pure fracture and health adult.To hope to provide theoretical foundation for the treatment of fracture.Method Sixty-four patients were divided into four groups.Each group was sixteen cases,including pure fracture,pure cerebral trauma,fracture associated with cerebral trauma and health adult whose age between twenty and seventy years,average forty-two years.The criterion of pure fracture is fracture of long tubular bone in the extremities.The criterion of cerebral trauma is coma,headache,vomit and symptom continue more than three days.Venous bleed of the panients were adopted at 1,3,7, 14 days after injury and Were freed thirty minutes in room temperature and were centrifuged to get the serums and were preserved under the temperature of-20℃.Experimentation were operated rigorously following explaination of case of EGF.Concentration of EGF in all sample were counted and draw conclusion through statistical analysis.Results In the third day EGF increases after injury in the group of pure cerebral trauma and pure fracture.It is twice in the first week and gets to three times in the second week as much as normal.In the group of cerebral trauma associated fracture EGF increases obviously.It is five times in the third day and gets to seven times in the first week as much as normal.In every period of time contrasted with the group of pure cerebral traulna or pure fracture it has statistical significance(p＜0.05).Conclusion EGF increases obviously in the group of cerebral trauma associated fracture.EGF maybe participates the process of fracture healing.