Research On Effects Of Spicy Foods To Epidermis Stimulation Of Imidazolidinyl Urea

Objective: Cosmetics antiseptic is the important reason of cosmetics dermatitis. In order to avoid dermatitis and allergic reactions, there are maximal concentrations for different cosmetics antiseptics. Recent research had shown that spicy foods could enhance the body local reactions. Present research is aimed to study the effects of spicy foods on epidermis stimulation induced by imidazolidinyl urea, a commonly used cosmetics antiseptic, so as to provide the data for the diagnosis and treatment of related diseases.Methods: In order to induce the rabbit model, 10% pepper fluid (10ml/kg weight), alcohol (2.0g/kg Weight) and pepper-alcohol mixture (5ml-2.0g/kg weight) were used to fill the stomach of rabbits once a day, saline was used as control. After 7 days, rabbits" symptom was observed and scored. Every group was divided into single skin stimulation tests and multiple skin stimulation tests, with integral and injured skin. 0.6% imidazolidinyl urea was applied on the skin once for single skin stimulation tests and once a day for 7 days for multiple skin stimulation tests. 24h later, general and histological reactions were observed and scored.Results: Compared with control, pepper, alcohol and mixture could all induce symptom of spicy foods stimulation and the score also increased progressively. The results of single skin stimulation tests showed that group alcohol and mixture had mild skin irritation with injured skin, and average histological scores 0.75 and 2.5 respectively. There is obvious difference compared with group control and pepper. The results of multiple skin stimulation tests showed that group alcohol and mixture had mild and moderate skin irritation with integral skin, respectively, with average histological score 2.0 and 4.5. There is significant difference compared with group control and pepper. Group pepper, alcohol and mixture had mild, moderate and severe skin irritation with injured skin, respectively, with average histological score 0.75, 8.25 and 13.0. There is significant difference compared with group control. There is obvious relation between general, histological scores and stomach-heat syndrome scores.Conclusion: With the dose used in present-study, pepper, alcohol and pepper-alcohol mixture could all induce spicy foods stimulation syndrome in rabbits successfully, and the degrees increased progressively. Hot stimulation could obviously enhance the epidermis stimulation of imidazolidinyl urea. We should concern about this in clinic.