Effect Of Curzerene Curing Breast Precancer Rats On The Blood Rheology And Mammary Microcirculation

Objective: To research the mechanism of treating breast precancer with Curzerene by measuring the blood rheology and mammary microcirculation of the animal model of breast precancer rats.Methods: 72 SD rats were randomly divided into five groups:the blank control group,the breast precancer model group, remedial groups of Curzerene,the comparative group of kanglaite,the comparative group of tamoxifen. Animal model of rat breast precancer was induced with DMBA. Interpose treatment was performed when the 10th week, and analysis of blood rheology,pathology and mammary microcirculation when the 14th week.Results: Compared with the blank control group,blood viscosity,plasma viscosity, deoxidize viscosity. the breast precancer model group increased (P<0.05),mammary microcirculation perfusion decreased (P<0.05).Blood viscosity,plasma viscosity, deoxidize viscosity Curzerene group got back to the normal level, mammary microcirculation comeback to the level of the blank control group,and had significant difference compared with the breast precancer model group( P<0.01).The treatment of remedial groups of Curzerene is better than the comparative group of kanglaite(p<0.01)and the comparative group of tamoxifen(P<0.05).Conclusion: Curzerene could cure and prevent breast precancer by influencing blood rheology and increasing perfusion of mammary microcirculation.