Research Of Equipment For Accelerating Wound Healing By Topical Oxygen Therapy Combined With Near-infrared LED Irradiation

Military medicine has faced a new challenge and requirement with the advancement of military transformation. In modern war, using of modern technology takes the accuracy and lethality of the weapons to make remarkable progress. It causes the number of the wounded to increase rapidly and dose great damage to the battle effectiveness of the army. Mass destruction weapons bring more difficulties to the first aid. Medical troops have heavier burdens in wartime than before. The advanced technology of trauma care plays a notable role in recovering and improving the battle effectiveness of the army. How to accelerate the wound healing and alleviate the pain of the wounded becomes a most urgent problem.The traditional trauma care has already not adapted for the war trauma in new period. As we know, the features of topical oxygen therapy (TOT) are portability, simplified operation and low cost. It can be used to accelerate many types of chronic non-healing wounds. Treatment of near-infrared light emitting diodes (NIR-LED) array irradiation is characterized by its small size, light weight, high efficiency and low cost. These advantages of TOT and NIR-LED array irradiation make them suitable for designing equipment for trauma care in field operations. The aim of the subject includes validating the feasibility of whether it can accelerate wound healing by combining TOT with NIR-LED array irradiation and designing an equipment which can care the wounded by combined means. There was no report about the combined means. It belongs to a new type of trauma care technique and the advent of the combined means enriches the theories of trauma care.Main jobs are listed as follows:1) Design of equipment for animal experimentsIt mainly involved the equipment of animal fixture, NIR irradiation, oxygen supply and so on. The equipment was used in the animal experiments and the results achieved as we have anticipated.2) Animal experimentAim: To investigate the influence of TOT combined with NIR-LED array irradiation on the wound healing of rabbits. Methods: Four pieces of full-thickness skin loss wounds were made on the back of every rabbit. Total eighty pieces of wounds were made on twenty rabbits. The rabbits were randomly divided into 4 groups (n=20): control group, TOT group, NIR-LED irradiation group, combining group(TOT combined with NIR-LED irradiation). The time which every healed wound needed to heal was recorded and used to make statistic analysis.Results: The wound healing time of four groups respectively was: (21.3±2.3)d,(19.6±2.2)d,(19.2±2.6)d,(18.0±2.1)d. The wound healing time of TOT group and NIR-LED group was lower than that of control group(p<0.05). The wound healing time of combining group was lower than those of control group(p<0.01) and TOT group(p<0.05).There was no significant difference of the wound healing time between combining group and NIR-LED group(p>0.05). Conclusion: The combined means can availably accelerate the wound healing of full-thickness skin loss wound animal model.3) Design of a wound area measurement system for studies of wound repair Aim: To design a wound area measurement system based on the digital image processing and then use the system in the animal experiment to measure the wound area. Methods: Set a reference object whose area is known to the wound and use the digital image processing to measure the wound area. Results: We used the system in the experiment of animal model and drew a wound area-time curve by the measurement result. Having observed the curve downtrend, we found that the speed of wound contraction was quickest at the beginning period of wound healing. Conclusion: The system is fit for studies of wound repair to measure the wound area. The measurement result showed that the promotion to wound healing by the combined means was most significant at the beginning period of wound healing.4) Design of equipment systemBased on the animal experiments, the equipment for the animal experiments was designed. It was based on the animal experiments and the design of equipment for the animal experiments. The design involved power unit, control unit, NIR-LED array unit and so on. The main aim of the design was to realize multifunction, portability, energy-saving and intelligentization. Design of NIR-LED array was one of the most important units. Since the NIR-LED irradiates NIR which is invisible light, we used MATLAB to simulate the NIR-LED array irradiation. By this means, it was easy to observe the NIR-LED array irradiation trend when one parameter just like distance of irradiation or the way of NIR-LED array arranging changed. The way of simulating can help us choose the optimal irradiation distance and the best way to array the NIR-LED.By the animal experiments, it has been proved that the feasibility of the combined means. Based on the theory of combined means, the equipment which we have designed is characterized by multifunction, portability, energy-saving and intelligentization. It is suitable for the war trauma.