| Objective:The observation invigorates the blood recovers the sore to disperse the treatment acute gastric mucosa pathological change's clinical curative effect and to the blood platelet tivation factor (PAF), blood plasma nitrogen monoxide (NO), the blood vessel bast element (ET) the influence.Methods:The observation case 48 examples, originate from this courtyard ER, the cerebrovascular disease branch, the ICU hospital ward patient (2006.3-2007.9).According to receives in hospital successively serial numbering, according to the stochastic tables,divides into the treatment group and the control group stochastically.The treatment group 24 examples (male 13 examples, female 11 examples, average age 54.29±10.98 year old, acute cerebrovascular disease 9 examples, infectiousness is in shock 7 examples, acute shouts fades 8 examples).The control group 24 examples (male 13 examples, female 11 examples, average age 55.38±12.37 year old,acute cerebrovascular disease 10 examples, infectiousness is in shock 9 examples, acute shouts fades 5 examples).Two groups in the age, the sex,aspects and so on condition degree after statistics processing,do not have the significance difference (P>0.05),has the commeasurability (Table 1,2,3).The treatment group gives invigorates the blood to recover the sore to disperse (lives Chinese rhubarb 12g, dried rehmannia 15g, three-seven powder 2g, fresh keel 12g, Chinese angelica 15g, herbaceous peony 12g, Baiji 6g, red kaolin 15g, mountain cornus 15g)to fry thickly by this courtyard preparation room takes juice 150ml,the stomach tube pours into,on first three times.The control group gives the armor cyanogen onamot guanidine 400mg dead center,on first two times.Two groups observe for five days.In the other remedial measure like anti-infection,the cause of disease treatment,the internal organs function support,the maintenance the environment is stable,nutrition support,just right for the illness treatment and so on two groups even same.After observing two groups treat,clinical curative effect,hematischesis time,in hospital time as well as to blood platelet tivation factor (PAF),blood plasma nitrogen monoxide (NO),bast element (ET) influence.Result:1.Two group of clinical curative effect comparisons. (Table4),the treatment group convalesces 12 examples,effective 10 examples, invalid 2 examples,total effectiveness 87.5%;The control group convalesces 9 examples,effective 7 examples, invalid 8 examples,total effectiveness 70.8%,X2=4.547, P=0.033<0.05.The treatment group and the control group comparison have the significance difference,prompts invigorates the blood to recover the sore to disperse the treatment group the clinical curative effect obviously to surpass the armor cyanogen onamot guanidine control group.2.Two group of patients stop bleeding the time, in hospital time comparison. (Fig.1,Table5), the treatment group patient's average hematischesis time for 24.11±7.03 the hour, the control group patient's hematischesis time for 39.58±23.08 the hour, two group of patients stops bleeding the time to compare T=3.1420 P=0.0029<0.05.Two groups of statistics have the significance difference, prompts invigorates the blood to recover the sore to disperse the treatment group to be able to reduce the patient bleeding time obviously to surpass the armor cyanogen onamot guanidine control groupafter statistics .The treatment group patient's average in hospital time for 21.19±4.96 the day, the control group patient's average in hospital time for 26.73±10.42 the day, two group of patients is hospitalized the time to compare T=2.3532 P=0.0229<0.05.Two groups of statistics have the significance difference, prompts invigorates the blood to recover the sore to disperse the treatment group to be able to reduce the patient to be hospitalized the time obviously to surpass the armor cyanogen onamot guanidine control group.3.Around two groups treat the blood platelet tivation factor (PAF) the content comparison. (Fig.2 , Table6),before the treatment group treats, the PAF content 12.35±0.86μg/L,after the treatment, the PAF content 7.65±1.79μg/L,around the treatment compares T=6.4102,P=0.0000<0.05.Has statistics significance.Before the control group treats,the PAF content 12.05±1.34μg/L, after the treatment, the PAF content 8.05±3.78μg/L, around the treatment compares T=4.2340, P=0.0159<0.05. Has statistics significance.After the treatment group treats,the PAF content 7.65±1.79μg/L,after the control group treats,the PAF content 8.05±3.78μg/L, two groups compare T=2.1423 P=0.0375<0.05.Two groups of statistics have the significance difference,prompts invigorates the blood to recover the sore to disperse with armor cyanogen onamot guanidine can reduce in the patient blood serum the PAF content, but invigorates the blood to recover the sore to disperse the treatment group obviously to surpass the armor cyanogen onamot guanidine control group.4.Around two groups treat the blood plasma nitrogen monoxide (NO) the content comparison. (Fig.3,Table7), before the treatment group treats, the NO content 41.38±2.02μmol/L, after the treatment, the NO content 68.23±14.79μmol/L, around the treatment compares T=8.8056, P=0.0000<0.05.Has statistics significance. Before the control group treats, the NO content 41.44±2.67μmol/L,after the treatment,the NO content 45.40±17.99μmol/L,around the treatment compares T=3.9868, P=0.0002<0.05.Has statistics significance. After the treatment group treats, the NO content 68.23±14.79μmol/L, after the control group treats, the NO content 45.40±17.99μmol/L, two groups compare T=4.8001 P=0.0000<0.05.Two groups of statistics have the significance difference, prompts invigorates the blood to recover the sore to disperse with armor cyanogen onamot guanidine can elevate in the patient blood serum the NO content, but invigorates the blood to recover the sore to disperse the treatment group obviously to surpass the armor cyanogen onamot guanidine control group. 5.Around two groups treat the blood plasma bast element (ET) the content comparison.(Fig.4 , Table8),before the treatment group treats,the ET content 107.15±4.37ng/L, after the treatment, the ET content 59.49±18.78ng/L,around the treatment compares T=7.5914,P=0.0000<0.05. Has statistics significance. Before the control group treats, the ET content 108.05±1.68ng/L, after the control group treats, the ET content 75.05±23.24ng/L, around the treatment compares T=2.4848, P=0.0167<0.05.Has statistics significance.After the treatment group treats, the ET content 59.49±18.78ng/L,after the control group treats, the ET content 75.05±23.24ng/L, two groups compare T=2.5508 P=0.0141<0.05.Two groups of statistics have the significance difference,prompts invigorates the blood to recover the sore to disperse with armor cyanogen onamot guanidine can reduce in the patient blood serum the ET content,but invigorates the blood to recover the sore to disperse the treatment group obviously to surpass the armor cyanogen onamot guanidine control group.Conclusions:This research indicated that invigorates the blood to recover the sore to disperse may have the promotion ulcer in the treatment acute gastric mucosa pathological change aspect to heal,to reduce the patient bleeding time,in hospital time, its curative effect and clinical applies the broad armor cyanogen onamot guanidine control group to compare, has the remarkable superiority.Its action mechanism possible to be possible to reduce blood platelet tivation factor (PAF),bast element (ET) the content and simultaneously enhances the blood plasma nitrogen monoxide (NO) the content with we to concern. The findings from the clinical curative effect angle, confirmed the liver to release the function anti- to wind with the ecchymosis are abnormally sparsely the acute gastric mucosa pathological change's pathogenesis and the morbidity key, invigorated the blood the hematischesis, the supple liver treated disorders of the liver to treat the group side medication to be possible promotion ulcer to heal in the treatment acute gastric mucosa pathological change aspect,to reduce the patient bleeding time, in hospital time clinical curative effect. Confirmed has invigorated the blood to recover the sore to disperse the treatment acute gastric mucosa pathological change's usability and the feasibility,took the motherland Chinese medicine, had the very good development prospect.
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