Study On The Relationship Between Hormone And Housewife's Hand Dermatitis In Climacteric Women

Objective:Housewife's Hand Dermatitis(HWHD) is a special term which is used to describe a kind of hand eczema ,which is mostly found among house-wives ,especially who are in greater contact with soap,detergents and water and still deal with housework. Housewife's Hand Dermatitis is a chronic irritant contact dermatitis .The aim of our study is to investigate the serum hormone level among patients and healthy women and explore the action and mechanism of hormone in HWHD .Methods:1,A survey of HWHD ,based on a questionnair, was carried out among 45 female patients.The questionnair includee questions on patient history,occupation, the frequence of household work, contacting materials ,antigents, patch testing, family allergic history ,etc.2,Bi-Antibodies Radioimmunoassy was used to measure the serum estrogen(Estrogen,E2),Follicle Stimulating Hormone(Follicle Stimulating Hormone,FSH) ,Luteinizing Hormone(Luteinizing Hormone,LH), Prolactin(Prolactin,PRL),Testosterone(Testosterone,T),Progesterone (Progesterone,P) among the 45 patients and 55 healthy women. And find the differences between the two groups.3,We examined and recorded the symtoms and locations of every patient by a Hand eczema severity Index (HECSI) detailedly.45 HWHD cases were investigated by a log-linear analysis method to evaluate the interaction of clinical manifestation and serum E2 levels.Results:1,Exogenous factors: Contacting with detergents , excessive washing and physical friction were identified as causing or contributing to the HWHD in 45 female patients. 2,Personal and family allergic history: In the 45 cases of the observation group ,35 cases or their family were said to have allergic diaeases .3,Allergic test and patch test: In the 45 cases of the observation group ,30cases were detected to have positive allergic test reaction and 15 cases have positive patch test reaction.The main allergens were fish,shrimps,cracks,eggs,milk,farinate,et al in allergic test. There are 10 cases(40.00%) have 4 kinds of positive allergens,9 cases (4.00%) have kinds of positive allergens, 5 cases(20.00%) have 2 kinds of positive allergens, 1 cases(36.00%) have 1 kinds of positive allergens. 4,Clinical manifestation: All of the 45cases suffered from itch in different degrees and 43 cases of them were observed to be revolved in both hands (84.44%).5,According to the results of testing on hormone, observation group (44.13±33.18) showed significantly lower E2 levels than control values (57.12±3.78) , and the comparison between the two groups has significance (P<0.05). Otherwise, observation group (0.39±0.17) showed significantly higher T levels than control values(0.32±0.14), and the comparison between the two groups has significance (P<0.05). Both observation and control groups showed downtrends on P and PRL ,meanwhile both of the two groups showed uptrends on FSH and LH ,without significance (P>0.05).The cases of FSH/LH>1.0 in the observation group are more than control group.6,According to the FSH/LH values,45 cases of HWHD are classified into peri-menopausal and menopausal groups.Meanwhile ,we evaluated the r(Pearson Correlation Cofficients) between hormones and HESCI.In the two groups, the r of E2 and HESCI both are -0.699,which is indicated a negative relationship between E2 levels and clinical menifestations.Conclusion:1,The main exogenous factors of HWHD is contacting with water and slkalinechemical materials in detergents.2,35 cases of HWHD had once allergic diseases or allergic family history ,whichindicated the heritage hypersensitiveness and heterogeneity of being allergic to foodand chemical materials are the endogenous factors of HWHD.3,All of the 45cases suffered from itch in different degrees and 43 cases of them wereobserved to be revolved in both hands.Besides,the HWHD are mainly stay in thechronic periods.4,Observation group (44.13±33.18) showed significantly lower E2 levels thancontrol values (57.12±3.78) , and the comparison between the two groups hassignificance (P<0.05). Otherwise, observation group ( 0.39±0.17 ) showedsignificantly higher T levels than control values(0.32±0.14), and the comparisonbetween the two groups has significance (P<0.05). It is indicated that the decline of serum E2 level may cause the occurrence and relapse of HWHD.5,It is recognized that there is a negative relationship between E2 levels and clinical menifestations(P<0.05),which indicated that E2 may have adverse influence on the relapse and aggravation of HWHD.