An Analysis Of Clinical Assessment And Etiological Of Hand Eczema

Objective: Hand eczema, hand eczema which also called hand inflammation, is an inflammatory disease of skin which can cause by many internal and external factors. It impacts on the quality of life and economic of patients seriously.Here, in this study wepatch tests and assess the severity with 93 cases of hand eczema patients. We combined with clinical history, observation and analysis the correlation of the pathogeny, morphologic classification, gender, age, occupation, contact history, allergens, severity, quality of life and other factors.Methods: 93 patients with hand eczema diagnosed by Department of Dermatology, Peking University Shenzhen Hospital. We asked medical history, records of age of onset, course of disease, course of treatment, occupation, allergic history, aggravating factors. The patients were scored by Hand Eczema Severity Index and Dermatology Life Quality Index. 93 patients were examined with European standard series patch tests and dust mite Atopic Patch Tests. All patients were classified by morphology and etiology.Result:Of the 58 patients with hand eczema, the ratio of male and female was 1:2.9, the average age was 33.37 + 1.25 years, the average course of disease was 3.97 + 0.47 years. 39.78% of all patients had an atopic history. There was no significant difference in atopic history, clinical types, etiology types between different gender. There was significant difference in pompholyx or non pompholyx between atopic history. Women wear glove significant more than men. There was no significant difference in time of wearing gloves between different duration. There was no significant difference in the time of handwashing, the time of access to water between different gender, duration of hand eczema. Of the 93 patients patch test with European standard series allergens, 47(50.53%) patients showed at least one positive reaction. The most common allergens were nickel sulphate, cobalt chloride, kathon CG, fragrance mixⅠ and potassium dichromate. The male with positive of potassium dichromate was significantly higher than female. 30 years or above in patients with positive of potassium dichromate was significantly higher than under the age of 30. Age, atopic history, morphological types did not affect the positive rate of patch test in patients with hand eczema. All patients patch test with dermatophagoides farinae/dermatophagoides pteronyssinus. 10(10.75%) patients showed at least one positive reaction. There was no significant difference in the positive rate of atopic patch test between different gender, atopic history, morphological types. The average of HECSI was 38.27±3.46. The average of DLQI was 11.09±0.68. The score of HECSI was positive correlation with the time of wearing gloves. There was no significant correlation was found for HECSI, DLQI and gender, age, duration, atopic history, the time of handwashing, the time of access to water, morphological types, pathogeny types. A statistically significant positive correlation between DLQI and HECSI was found.Conclusion: The patients of Pompholyx with atopic history was significantly higher than non pompholyx. Women wear glove significant more than men. The most common allergens were nickel sulphate, cobalt chloride, kathon CG, fragrance mixⅠ and potassium dichromate. The male with positive of potassium dichromate was significantly higher than female. The more time of wearing gloves, the degree of hand eczema is more serious. The patients with serious of hand eczema had a negative impact on their quality of life.