The Effect Of Exercise On Serum Hormone And Ovarian Morphology In Rats With Polycystic Ovary Syndrome

Objective: We explored the effect of exercise on serum insulin, serum sex hormone and ovarian morphology in rats with polycystic ovary syndrome.Method: 17 Wistar rats of 21-day-old were randomly divided to PCOS exercise group (n=6), PCOS non-exercise group (n=6) and non-PCOS control group (n=5). PCOS models were induced by injection of testosterone propionate dissolved in tea oil, while control rats were injected with tea oil. The exercise rats were trained by swimming with 120 min/d for 15 days. At the end of the experiment, the blood glucose and insulin (INS), estrogen (E₂), progesterone (P) and testosterone (T) in serum were determined by RIA and ovarian morphology was evaluated by Image-Pro Plus 6.0.Result: The levels of INS, E₂, P and T in serum were significantly lower in PCOS exercise group than that in non-exercise group. The ratios of FBG/FINS in PCOS exercise group increased significantly compared with PCOS non-exercise group. The levels of serum sex hormones in PCOS exercise group were similar to non-PCOS control group. There were no differences in blood glucose and serum progesterone among three groups. Ovarian morphology showed that the amounts of preantral follicles and atretic follicles significantly decreased (p<0.05) and the amounts of antral follicles and corpus luteum significantly increased (p<0.05) in PCOS exercise group compared with PCOS non-exercise group. The changes of ovarian morphology in PCOS exercise group were similar to non-PCOS control group.Conclusion: Short-term exercise training can improve insulin sensibility, decrease the levels of serum androgen and E₂, and recover normal ovarian morphology, suggesting that exercise training is the basic therapeutic means for patients with PCOS.