Follow-up And Analysis Of The Diseases Of Prostate In The Aged Men With Abnormal PSA Level In Fuzhou Area

Purpose: To study the value of prostate-specific antigen(PSA) for the diagnosis of prostate cancer(Pca) in aged men in FuZhou area by investigating the relationship among the aged men with disease of prostate, PSA and prostate volume(PV).Methods: From December of 2006 to December of 2007, Digital rectal examination(DRE) and PSA measure were performed in 1234 men( over 50 years) in FuZhou area , and further examinations including transrectal ultrasound(TRUS), PV and prostate biophy were performed in the patients with PSA>4 ng/ml. PSA and PV between the group of Benign prostate hyperplasia (BPH) and Pca were compared, and PSA level in different patients was also compared.Results: We investigated 1234 old men in all, and 146 men with PSA level over 4 ng/ml were found. 126 men in these 146 cases were followed up, and were accepted "10 spot" prostate biopsy through TRUS. BPH was diagnosed in 101 men and PCa was diagnosed in 25 men by prostate biopsy. We found that the concentration of PSA was higher following the age increasing, PSA in 50-59 year group is 5.5±4.1 ng/ml, 60-69 is 6.8±8.2 ng/ml, 70-79 is 8.6±15.2 ng/ml, but after 70 it has only a little change. There was no relationship between patient age and PSA(P>0.05), but the prostate volume had a significant correlation with age(P<0.05) . PSA levels had significant difference between the groups of BPH and PCa (resepectily 8.4±14.2ng/ml and 29.3±17.5 ng/ml ) ( t= 6.2810,P<0.05 ) ,but prostate volums(resepectily 32.61±16.19ml and 36.13±12.73ml) had no significant difference (P>0.05) . Pca incidence in PSA>10ng/ml group was higher than in PSA>4.0ng/ml (P<0.05) .Conclusions: In FuZhou area, PSA was an important tumor marker for prostate cancer. "10 spot" prostate biopsy was an effective method in the diagnosis of prostate cancer. The patients of PSA over 4.0ng/ml should be followed-up closely. For them, prostate biopsy was recommended. When the concentration of PSA is more than 10ng/ml, we should be on guard against prostate carcinogenesis.