The Study Of Transition Zone Volume And The Difference Of The Serum Prostate Specific Antigen Which Obtained Pre-oprerative And Post-operative In Benign Prostate Hyperplasia

IntroductionThe prostate special antigen(PSA)is the single chain glycoprotain which is composed of 237 amino acids remnant and its relative molecular weight approximately is 34 000, PSA is produced by the prostategland epithelial cell, whose function is one kind of silk aminoacid proteinase which belongs to the kind stirs up the peptide release enzyme.At present the PSA detection has already become a very important biologytarget of the prostate cancer screen, the early diagnosis, by stages prognosis, the appraisal curative effect, making follow-up visit the observation and the most sensitive tumorsign of diagnosis the prostate gland cancer. But a part of benign prostate hyperplasia(BPH)patient and PC patient's PSA have overlaps, therefore the PSA sensitivity and the specificity receive a certain limit. Because the prostate gland volume and its the volume of transition zone influenced quite to PSA, this article which accepts the 60 treatment BPH patient' prostate gland the volume of transition zone and the around surgery to the PSA defficience value carries on the analysis appraisal from March, 2005 to March, 2006.Material and method1. Experimental materialsCollecting in 2005. 3 to 2006. 3 China medical university attachedabundant Shengjing hospital urology surgical department's BPH patient's the blood serum PSA value around the surgery and after the supersonicexamination prostate transition zone volume in 2005. 3 and 2006. 3. 2. Main reagentsThe PSA examination reagent box provided by the American yapei company, uses the enzyme to exempt microparticle throws oneself seizessends. Useing the 5. 5～7. 5MHZ frequencyconversion biplane to poke head in supersonic after the rectum of ESAOTE IDEA Corporation.3. Experimental techniqueProstate gland inspection(digital rectum examination, prostate gland massage, prostate gland puncture)around a week extracts 2 ml to supply the determination, using immunity biochemistry response survey blood serum PSA the density. After rectumsupersonic examination prostate transition zone volume size.4. Statistical methodUsing the SPSS 10. 0 software package to carry on the data processing, around the surgery the PSA value comparison uses the T examination analysis and 95% credible sector appraised, examination standard (P) double side 0. 05.Experimental resultIn 60 examples BPH the patient' surgery latter 58 patients PSA level drops, equally drops 1.913 ng/ml, and 2 examples' the PSA level elevate, equally elevates 7. 11 ng/ml.In front of the surgery PSA is(7.570±5.505)ng/ml; after the surgery PSA is (2.281±1.402)ng/ml; around the surgery the PSA difference value is(5.278±4.289) ng/ml.Around surgery the PSA deficience value and transition zone volume regression doefficient b = 0.521; correlation coefficient r = 0.754. Around the surgery the blood serum PSA value comparing the differences of two groups have remarkable(P＜0.05)In front of surgery PSA 95% credibly limits is 7.570±2×5.055/(60^1/2)(6.265,8.875); post operation PSA 95% credibly limits =2.281±2×1.402/(60^1/2)(1.919,2.643). Around the surgery the scope of PSA credibly limits donot overlap,which proved the difference is remarkable(P＜0.05)Straight line regression equation (?)=4.998+0.521X (PSA= (?) prostate transition volume =x regression doefficient =b), which indicated around the surgery the blood serum PSA existence straight line correlation,transition zone volume every time changes 10cm³ PSA on correspondingly to change 0.521 ng/ml; PSA and transition zone volume obvious have correlation(P＜0.05).ConclusionThis research is for further proved the relations of blood serum PSA and transition zone, the former research is mostly about the correlation analysis of PSA and the prostate gland volume.This research is about that transition zone belt is the main part of the blood serum PSA and the surgery main excision part and the transition zone'remove has caused the PSA drop, dropped partial and the transition zone has the obvious correlational dependence, had proven transition zone was the PSA main secretion spot. The BPH patient whosr PSA is slightly higher than the normal value may do the prostate gland surgery(for example the TURP technique), then if the technique PSA droped, it is BPH, otherwise PSA does not drop or elevates, then has the possibility which the prostate gland cancer exists.