Bu Shen Soup Is The Treatment Of Lucocrticoid-Induced Osteorosis Exprimental Study

Objective:This study is by observing Bushen soup of glucocorticoid-induced osteoporosis bone density of rats,bone structure and on serum calcium,phosphorus content,calcitonin,the level of sex hormones,to explore its control sugar Glucocorticoid-induced osteoporosis and the efficacy of the mechanism.Methods:healthy 3-month-old Wistar rats were injected with dexamethasone-induced osteoporosis model of success,were divided into six groups,in addition to the blank group and the control group,respectively Bushen soup is high,Medium and low-dose D and calcium Welch garage treatment.8 W treatment,the blood of rats in each group, centrifugal from serum.From rats bilateral femur.Dual-energy X-ray to measure the density of bone mineral density;digital photography microscope BMP;biochemical Determination of serum phosphate,calcium and RIA used in the determination of estrogen and calcitonin,testosterone levels and all groups Model T group to group test analysis and comparison.Results:Bushen soup is high-dose group was significantly higher than that of bone mineral density in the model group(P＜0.05),serum estrogen and calcitonin,testosterone levels and blood calcium levels are significantly higher than the model group(p＜0.05); morphology can be seen:Bushen soup is high-dose group and the model group,compared to the top of the femur bone-lined;normal bone marrow cavity,the space of a few lacunae decreased significantly.Conclusion:The experiments show that it is Bushen soup can increase glucocorticoid-induced osteoporosis bone density of rats,to improve its osteoporosis.The mechanism is that by the serum levels of the hormone to regulate and control,and promote absorption of calcium,such as multi-channel,multi-target role.To increase bone formation,bone loss reduction in bone be strengthened and restored,thus prevention of glucocorticoid-induced osteoporosis.The result indicated that presses is invigorating the kidney fills in the marrow,to be good for the spleen the principle of reatment group side which the blood tonic,the blood circulation set a broken bone to invigorate the kidney the solid bone soup to the model big mouse to have the good therapeutic action,thus for this side near the card application,has provided the reliable experiment basis.