| Objectives:To explore the Effects of the Kangxin Capsule on hyperlipidemic rabbits with steatohepatitMethods:Establish the model by the rabbits'carotid followed with high cholesterol feeding for six weeks. Randomly divided forty healthy male New Zealand white rabbits into five groups: model group, the Atorvastatin Calcium treating group, small-dose Kangxin group, large-dose Kangxin group, and control group. To test the expression of TNF-αand TGF-βin the liver with immunohistochemistry and also the expression of TNF-αmRNA and TGF-βmRNA in the liver with RT-PCR; and observe the morphology of the liver and make a pathological analysis.Results:Compared with the model group, the level of the blood lipid, the protein content of liver such as TNF-αand TGF-βand the expression of TNF-αmRNA and TNF-αmRNA are degrade in the Kangxin-treated group. The differences are significant (P<0.05or P<0.01). The effect of large-dose Kangxin group shows synergic effects.Conclusion:Kangxin capsule can reduce Tc,Tg, LDL-C, and hs-CRP, Fib, lower the expression of mediators of inflammation such as TNF-α, TNF-α, hs-CRP, and probably promote the recover of hyperlipidemic steatohepatitis in hyperlipidemic rabbits. |
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