A 1:1 Case-Control Study On Risk Factors Of Gastric Cancer

Objective: Through the investigation and the statistical analysis of Dalian female primary Gastric cancer patients to explore the related risk factors that affect the occurrence of Gastric cancer, provide reference for the prevention of Gastric cancer.Methods: A 1:1 matched case-control study was carried out in Dalian including 200 cases with Gastric cancer and 200 controls. Data were analyzed with Chi-square test, nonparametric test and the conditional Logistic regression, then calculated the Odds Ratio and the 95% confidence. Cases were choice from in hospital patients who had diagnosed colorectal cancer in nearly one or two years. According to the principle of 1:1 matched case-control study, controls were paired to cases with age that younger or older 3 years old, same gender and cases must be non-cancer, no digestive apparatus disease patients. Cases and controls were requested must have lived in Dalian more than 10 years.Results: Through the Conditional logistic regression analysis we found that the income and consume per month ten years ago, repair in recent ten years, drinking tea, gastric ulcer history, gastritis history, the directly- related family members have tumor history, not eat breakfast, dinners are not timed, Binge overeating, intake fried food, baked food, dried and hard food frequently, addict in acrimonious and salty food, eat when angry, intake garlic, fruits and vegetables frequently, experienced negative event, have the pressure in living and working, pessimistically, easily angry , do not like communicate with people, depression and so on are risk factors of Gastric cancer. The multi-factor conditional logistic regression analysis result showed: the low consume per month ten years ago, repair in recent ten years, intake baked food frequently, eat when angry, addict in acrimonious and salty food, have the pressure in living and working, easily angry are the risk factors of Gastric cancer, while intake garlic and vegetables frequently are protective factors of Gastric cancer.Conclusion: Gastric cancer is the result of many factors. We should adopt the comprehensive nature and the target-oriented measure for the prevention of Gastric cancer.