| Context&Objective: Parathyroid carcinoma is a rare malignancy, the etiology of the tumour remains unclear. Because the disease is so uncommon, our experience of parathyroid carcinoma mainly derives from case reports and a few retrospective studies. The poor recongention may leads to misdiagnosis. The aim of this article is to explore the clinical characteristics, diagnosis and treatment of parathyroid with the clinical cases.Material&Methods: The clinical data of 3 cases of parathyroid carcinoma, collected in 2nd affiliated hospital Zhejiang University college of medicine from Sep 2001 to Sep 2007, were reviewed and analyzed retrospectively. All cases were confirmed by pathological examination after surgery and followed up. Literatures were reviewed accordingly.Results&Conclusions: All 3 cases with parathyroid carcinoma were misdiagnosed before surgery, suggestive of enhancing consciousness of the disease. The main clinical presentations of patients with PC are a palpable cervical mass and concomitant kidney and bone diseases mainly related to the severely increased secretion of PTH. The pre-operative diagnosis of malignancy is very difficult, and, thus, intra-operative recognition of PC is mandatory. Serum calcium and PTH assay should be performed as a routine screening procedure. A combination of ultrasonography and 99mTc-MIBI scintigraphy is sufficient for locating the tumor. Surgical resection is the most effective treatment of Pc. The en bloc resection of the tumour represents the gold standard of initial surgical treatment of patients. Whereas the radiotherapy is an alternative for later unresected cases.
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