| Background: Chronic fatigue syndrome, or CFS, is a complex symptom group characterized by neuro-psychiatric symptoms and long time of chronic fatigue that can be not improved by taking rest, and without organic and mental diseases. With the development of modern society, patients basically be action in mental stress and chronic fatigue are piling up in the high-tempo and high-stress environment. CFS gradually became one of the main problems to harm people' s mental health and quality of life.The etiology and pathogenesis of CFS has still been unknown so far. It' s believed that the inducement is in connection with virus infection, stress and so on. The research of pathogenesis main focus on the abnormity of nervous system (such as NK, PBL), endocrine system( such as GH, PRl) and immunologic system. All the treatments are not specifically aimed at pathogenic cure, but just be calculated to reduce the severity. The clinical manifestations of CFS patients are varied. Many patients shows obvious depression, except for the typical fatigue. The negative mental state, without out treatment in time, will not only make the disease deteriorated, but also has the possibility to develop into tristimania.In Chinese traditional medicine, there is no documents related to CFS, but as the common clinical syndrome, fatigue could often be found in old Chinese medical books. Some doctors considered CFS to be in the field of consumptive disease because its alike clinical syndrome with consumptive disease. Considering all the viewpoints, CFS major result of affect-mind factor. With the development of modern society, irregular hours and overtired becomes the reason of weakness of Zang and Fu, lack of Qi, Blood, Yin and Yang, dysfunction of Qi and disorder of Qi transformation of five zang organs. CFS is mainly located in liver, spleen and kidney, but involved in five zang organs. Based on long-term clinical practice, my tutor expounds the pathogenesis of CFS. He thinks that the basic precipitating factor is the deficiency of Qi. CFS has a long course and develop slowly. It involves five zang organs step by step from light to severe result in the functional disorders and spirit deficiency of five zang organs. Spirit deficiency leads to the stagnation of qi, blood, phlegm-dampness and collateral which cause several different clinical manifestations. Acupuncture is one of the most effective treatments with simple, convenient and inexpensive characters. However, there are still many deficiencies such as nonstandard syndrome differentiation, distinct standard for acupoint selection and so on; what' s more there is little objective evaluation of clinical treatments. More improvements for acupuncture therapy need to be carried out. In the future, we should ponder and implement to make more use of acupuncture therapy for society.Purpose: Through objectively evaluating the curative efficiency of acupuncture therapy under Qijie theory in improve the depression state and level of correlated pituitary hormone of CFS patients, we supposed to explore the implications that the Qijie theory has for acupuncture treatment and to supply clinical evidence for standard of acupuncture treatment. And we plan to briefly discuss the the pathogenesis of CFS' s depression character. Method: Divide 60 qualified patients into treatment group and control group, 30 for each group. Do acupuncture on Baihui, Fengfu, Renying for treatment group, and the others receive intravenous Shenmai injection for control. Use Self-rating Depression Scale to rate the 60 testees and detect the level of PRL and GH separately at the beginning and the end of the treatment. Results: According to the SDS scales before treating, there wee 49 patients can be diagnosed with depression, among which 29 were mild depression and 19 were moderate depression. Compared by t-test, SDS scores, level of PRL and GH were significantly changed (P<0. 05).Conclusions: Result shows that the depression state of CFS is mainly mild and moderate. In treatment, both acupuncture and Shenmai injection are effective for depression state of CFS, and acupuncture is more effective. Foundational levels of PRL and GH have been significantly changed. It shows that these two therapies are useful of improving the abnormal levels of PRL and Gh, and there is no significant difference between the efficiency of two treatments. In this research, the scores of SDS had no correlation with the levels of PRL and GH. It suggests that endocrine disorder cannot be consider as the direct or main pathogenesis for depression state of CFS by now. |
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