| Objective To investigate the influence of depression on serum interleukin-1βlevel of middle age and elderly patients with coronary hear disease of stable angina pectoris. Methods Eighty-six (age≥50) middle aged and elderly (aging ) patients with coronary hear disease of stable angina pectoris who were admitted to our department from Augest2007 to December2007 recruited to our study. According to ZHUG questionnaire (SDS) score whether accompanied with depression or not 86 patients divided into two groups. There were 62 patients in Group A (patients with depression) and 24 patients in group B (patients without depression) respectively. We analyzed clinical data, serum lipid, blood glucose and interleukin-1βlevel of two groups. Results There was no significant difference between two groups when compare age, sex, smoking, drinking, education, accompany with hypertension, accompany with diabetic (P>0.05). The level of interleukin-1βin coronary hear disease accompany with depression higher than coronary hear disease without depression and significant different with without depression group, P<0.05. Correlation analysis results showed that SDS score was positive related to interleukin-1β, r was 0.3547, P<0.01. No significant different between two groups on lipid level and no related to interleukin-1B (P>0.05). Conclusion The level of interleukin-1βin coronary heart disease accompany with depression higher than coronary hear disease without depression and positive related to depression degrees. The study showed that depression through immune inflammatory cytokines effect to cause, developing, prognosis of coronary hear disease, it is one of the predictor factor of poor prognosis in coronary hear disease.
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