Study On Protecting Effects Of Aqueous Extract Of Alcohol Of The Roots Of Apium Graveolens L For Acute Liver Injury, And The Influence Of Aqueous Extract Of Alcohol Of The Roots Of Apium Graveolens L On Hyperlipidemia Rat Model

Objective: To observe the effect of aqueous extract of alcohol of the roots of Apium graveolens L on the acute liver injury that induced by carbon tetrachloride (CCl4),D-Galactasamine (D-GaIN) and paracetamol(PAR). And to observe the influence of aqueous extract of alcohol of the roots of Apium graveolens L on experimental hyperlipidemia of rats. Methods: (1)Experimental hepatitis animal models were established in wistar rats by an single intraperitoneal injection of CCl(41ml/kg),D-GaIN(500mg/kg),and an single intraperitoneal injection of PAR(300mg/kg )in mice,respectively. Serum Alanine transferase(ALT), Aspartate tranfe- rase(AST), liver Super oxide dismutase (SOD), Malondialdehyde(MDA) were examined. Also histopathological changes in the liver tissue were observed. (2)Set up the rats hyperlipidemia model by ig lipid emulsion, rats that in treatment groups were continually given aqueous extract of alcohol of the roots of Apium graveolens L at dosages of 3g/kg,1.5g/kg separately for 30 days. The serum levels of CHO, TG ,HDL-C, LDL-C, SOD, and MDA of rat were examined after 30 days. Results: (1)Both dosages of aqueous extract of alcohol of the roots of Apium graveolens L significantly decreased serum ALT and AST elevation and the high-dosage increased the SOD activities while lowered MDA content significantly in the CCl4 and D-GaIN induced hepatitis model. Both dosages of aqueous extract of alcohol of the roots of Apium graveolens L increased the SOD activities while lowered MDA content significantly in the PAR induced hepatitis model. And the high-dosage significantly decreased serum ALT and AST elevation. It was concl- uded that the aqueous extract of alcohol of roots of Apium graveolens L possesses a significant hepatoprotection against the three kinds of chemical induced hepatitis. (2)The aqueous extract of alcohol of the roots of Apium graveolens L significantly decreased serum CHO,TG,LDL-C and MDA, increased HDL-C and SOD on experimental hyperlipidemia of rats. Conclusion: The aqueous extract of alcohol of the roots of Apium graveolens L has protective effects for acute liver injury in rats induced by CCl4,D-GalNand PAR. It could reduce the level of blood lipids on experimental hyperlipidemia of rats.