Distribution Of 3 Kinds Of Periodontal Pathogens In Subgingival Plaques In Chronic Periodontitis Patients And Coronary Heart Diseas

Objective The aim of this study was to investigate the prevalence of periodontal pathogens in Chinese chronic periodontitis (CP) patients and coronary heart disease (CHD)by PCR, and investigate the level of 3 Periodontal Pathogens in subgingival plaques of patients with chronic periodontitis patients and coronary heart disease and explore the correlation between the level of 3 periodontal pathogens and the two diseases. Methods A total of 132 male subjects, were included in this study. (62CP patients and 70 CHD. Bacteria DNA were extracted for detection of Phyromonas gingivalis(P.g),Tannerella forsythensis (T.f)and Prevotella intermedia(P.i) by 16 SrRNA PCR. Clinical assessments including probing depth,clinical attachment loss and lossing teeth were made at sampling sites. Results The prevalence of T.f in controls was 85.71%,70.37%,80.95% in initial CP,moderate CP and severe CP respectively.In CHD with CP tearm, The prevalence of T.f was 66.67%,71.43%,92.50% respectively in initial CP,moderate CP and severe CP respectively ,with significant difference between them (P <0. 05).The prevalence of P.g in two different degegree CP is 21.43%,55.56%,42.86% and 22.23%,52.38%,35.00% respectively. The prevalence of P.i in two different degegree CP is 0.00%,14.81%,4.77% and 22.23%,42.86%,47.50% respectively. T.f and P.g were found to be related with each other in CHD and CP ( P<0.05) Conclusion (1) In 3 Periodontal Pathogens, The prevalence of T.f in subgingival plaques of CHD and CP is different from CP,and higher in CHD and CP. (2) T.f and P.g were found to be related with each other in CHD and CP ( P<0.05)...