A Study Of Epidemiology On The Surveillance Site Of Drug Users By Using HIV-1 BED-CEIA

Objective To detect HIV recent infection in drug users using BED-CEIA and estimate HIV-1 incidence rate in Urumqi from 2000 to 2006, and evaluate of reproducibility and stability of the test ,combine laboratory results of recent infection using BED-CEIA and sentinel surveillance data ,and provide data laboratory to estimate effect of preventions and treatment of HIV/AIDS. Methods To collect,enter,sort and analise epidemiology information and date in hand of drug users in Urumqi from Jan.2000 to Dec.2006 with EXCEL and PEMS3.1.Results The CV of OD CAL,LPC and HPC were under 15% , the CV of OD-n LPC and HPC were under 7%.Among 12326 drug users,3686 were HIV-1 positive, among 2084 recruited HIV-1 positive samples for BED-CEIA,405 were recent infected.A decreasing trend in estimated HIV-1 incidence rates were observed between 2000 and 2005 ,but a marked declining trend in 2006 .Incidence rates of seven years were different significantly(X2=43.46,P<0.05).The incidence rate (7.8%) by BED-CEIA and reported incidence rate (8.8%) by HPTN033 cohort study were not differet significantly in the same target population. Females incidence rates was higher than males'(X2=25.8,P<0.05). Prevalence rates of uygurt nationality was higher than others(X2=28.0,P<0.05). There was no significant different between the population who had college education background and other lower education background from 2004 to 2006(P>0.05). The change of prebelance rate was much greater than its incidence rate among the smallest group.Injection drug users (IDUs) were mainly population in this surveillance site from 2000 to 2006. The prevalence rates of IDUs is higher than average level in this site (X2=259.8,P<0.05).Female prevalence rate is lower in 1998 than in 2005(P<0.05). Conclusion The performance of BED- CEIA in terms of its reproducibility and stability is excellent.Incidence rate from BED-CEIA is same as that from cohort study in 2002. There was a significant decrease trend in terms of incidence rate among IDUs in Urumqi. We should pay attention to female,uyget,married,college students and smallest ago group .We must strengthen health education , increase the intensity of monitoring and in-depth interventions in order to change their behavior.