Relationship Between Severity Of Coronary Artery Stenosis With Plasma Levels Of B-type Natriuretic Peptide

Objective To study the relationship between severity of coronary artery stenosis with plasma levels of B-type natriuretic peptide in the patients with coronary atherosclerotic heart disease. Methods The data, including body weight index(BMI), smoking history, blood lipids, brain natriuretic peptide(BNP), echocardiography (ECG), hepatic and renal function, were collected from the people who admitted to our center of cardiology for coronary angiography(CAG) from the year April 2006 to October 2006. 138 patients(male90,female48) ,aging 36 to 79(average60.58±10.22), were divided into normal ,single, double and multivessel coronary artery disease group by the severity of coronary artery stenosis.It were also divided into normal, stable angina pectoris ( SAP) and unstable angina pectoris (UAP) group by the characteristic of chest pain. The severity of coronary artery stenosis were evaluated through Gensini score system. Results An increase in blood pressure, blood glucose, creatinine, uric acid, low density lipoprotein;(LDL),smoking was observed in the coronary artery disease(CHD) groups compared with the normal group.The statistic differences in blood glucose and blood pressure were found between the CHD groups and normal group. Patients with CHD had lower high density lipoprotein(HDL)levels than normal group. There were statistic significance between multi vessel disease group and normal group in blood pressure, blood glucose, creatinine, uric acid, LDL,smoking and HDL. E/A are less than in double vessel disease and multi vessel disease group. BNP levels in CHD group were higher than normal group, but there were significantly higher BNP levels in patients with multi vessel disease than in those with single vessel, double vessel disease and normal group. Gensini scores in CHD group were higher than normal group and it showed statistic differences in multi vessel disease group compared with single vessel, double vessel disease and normal group. Patients with UAP had higher BNP levels than those with SAP and normal group. Gensini scores in UAP and SAP group were higher than normal, but no statistic significance in it. Conclusion Multivessel coronary artery disease was associated with diabetes mellitus, hypertension, high serum creatinine, high uric acid,age and smoking. Plasma BNP levels appeared elevated in patients with multi vessel coronary artery disease. Plasma levels of BNP correlates with multi vessel coronary artery disease. It may be an important clinical parameter to reflect the severity of coronary artery stenosis. High BNP level is an sign of UAP.