The Clinical And Experimental Research On Osteoarthritis Of The Knee Joints Treated By Prescription Of Enriching The Yang And Aliving The Blood(PEYAB)

Osteoarthritis of knee joints is one of common diseases and difficult diseases of orthopaedics, whose etiology and pathogenesis has yet elucidated completely, and there is no specific medicines that can cure it clinically. At the same time , it's incidence and deforming rate are highly. The principles of Chinese Traditional Medicine believe that the disease belongs to the areas of "arthromyodynia", its basic pathogenesis: deficience of liver,spleen and kidney, external evil factor attacks, stagnant blood obstructs meridian and damp and turbid stagnate. Based on the principles of Chinese Medicine, we carry out composition of formula and compatibility of medicines and create PEYAB to cure those of insufficiency of Yang and blood stasis undertake clinical observation and research. The results indicate that PEYAB has exactly therapeutic effect, and the total efficiency of 86.7%, with efficacy superior to the normal group. We believe that clinical efficacy of Chinese Medicine preparations treating osteal arthritis of the knee joints is sure; experimental research shows that PEYAB can treat the disease by mechanism of actions—clearing and inhibiting free radicle; relieving the changes of cartilage inflammation ; inhibiting synthetic action factor of matrix metalloproteinase ; depressing the pressure in the bone and improving the micro-circulation .