| PURPOSE: To quantify left ventricular function derived from retrospectively ECG-gated 64-detector-row computed tomography coronary angiography date sets in comparison to echocardiography imaging as the reference (LV) standard so as to investigate the clinical feasibility in evaluation the left ventricular volume and function with 64-MDCT.SUBJECTS AND METHODS: Multiplanar reformations in the short-axis orientation were calculated from axial contrast-enhanced CT mages in 42 patients(25 male, 17 female; age range 21-79 years, mean 56.3±6.8 years) referred for CT coronary angiography. The LV end-diastolic volume(LVEDV), end-systolic volume(LVESV), stroke volume(SV) and ejection fraction(EF) of the reformatted images were analyzed with a imaging software using an automated contour detection algorithm of left ventricular endo- and epicardial contours and by manual tracting. The date were compared with volumetric measurements based on echocardiography.RESULTS: EDV, ESV, SV and EF of the left ventricle derived from an automated contour detection algorithm were not statistically significantly different from manual tracing(CT-auto vs CT-manual: EDV=137.25±73.42ml vs 136.21±72.85ml, ESV=57.4±52.6ml vs 53.3±53.2ml, SV=79.85±26.2ml vs 82.9±26.13ml, EF=61.58±14.3% vs 64.70±12.87%; P＞0.05). However, EDV(109.15±46.45ml), ESV(38.46±25.14ml), SV(70.35±25.32ml) as calculated on echocardiography date set were statistically significantly different from those calculated on 64-MDCT (P＜0.05), whereas echocardiography-based EF(65.80±9.15%) did not differ statistically significantly from those calculated on both 64-MDCT algorithms(P＞0.05)CONCLUSION: As a new approach, cardiac 64-MDCT provides highly reproducible measurements of left ventricular function date which correlated well to echocardiography. This appears is feasible and reliable assessment of left ventricular function and volumes with 64-MDCT.
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