Preparation And Biocompatibility Of Polyurethane/Cellulose Liquid Crystal Compound Membrane

The liquid crystal structure plays an important role in organism's metabolism process. In21st century, through simulates vivo-liquid crystal environment to construct goodbiocompatibility polymer liquid crystal material is a new aspect of biomaterial research.A room temperature cellulose derivative liquid crystal—Butyric ester of hydroxypropylcellulose (BPC) was synthesized in this paper, and characterized by IR, ~1H NMR, POM and DSC.The results show that BPC was a thermotropic cholesteric liquid crystals, the phase transitiontemperatures of products reduced when the amount of Butyric acyl chloride added or the reactiontemperature increased. The BPC/PU compound membranes were prepared by solution castingtechnology. The observation results from POM, SEM, and AFM showed that the liquid crystal/polyurethane composite membranes surface displayed "island" phase separation structure andthe liquid crystal domain has the micro area orientation structure. The contact angle testindicated that the hydrophilicity and the surface tension increased with the increase of liquidcrystal. The hematolysis, the dynamic hemoglutination and the platelet test results todemonstrate that BPC could improve the anticoagulation. The protein adsorption was studied byusing the quartz crystal microbalance (QCM). The result indicated that hydrophilic material wasbad for protein adsorption. The results of the cell toxicity test and cell form observation showedthat the cell could grow well on the liquid crystal compound membranes. Therefore, the cellulosemodified liquid crystal material may provide the new mentality for the design goodbiocompatible material.