Inhibitory Effects Of Corni Fructus On Compound48/80-induced Mast Cell Activation And Vasular Permeability

OBJECTIVE The fruit of Corni fructus(CF), a perennial herb, is believed tohave anti-allergy effects, but its mechanism is unkown. The purpose of this studyis to investigate the inhibitory effect of CF on compound 48/80-induced mastcell activation.METHODS For this, the effects of CF on the degranulation, the histaminerelease, the calcium influx and the change of the intracellular cAMP levels of ratperitoneal mast cells(RPMC) and influences of CF on the compound 48/80-induced cutaneous reation were studied.RESULTS The results were as follows; the compound48/80-induceddegranulation, intracelluar calcium influx and histamine release of RPMC wassignificantly inhibited by pretreatment with CF,CF significantly inhibitedcompound 48/80-induced vascular permeability of rat cutaneous tissue. Fromthe above results.CONCLUSIONS it is suggested that CF contains some substances whichinhibit the compound 48/80-induced vascular permeability and mast cellactivation.