The Study Of Risk Factors Of Mild Cognitive Impairment In Community

Modern research showed that morbidity of AD has an obvious tendency of rising. AD drew a wide concern of medical field because of its high morbidity,high disability rate and the huge pressure imposed on the society and its families. But no satisfactory drug or medications were found till now.The research of Mild Cognitive Impairment(MCI)is the hot issue for AD rebounding to identify the high-risk individual and to found out the methods of prevention.Objective:1 To observe the epidemic distribute of the MCI;2 To explore the risk factors of MCI in the community;3 To explore the relation between zone and cognitive ability and the function of zone in predicting cognitive descending.Methods:We make investigation of the cross-sectional states about≥60 years old people by typical sampling during 2006.09 and 2006.12 in the community of Tijuana. The following items were investigated;cognitive examination,social demographic character investigation and physical examination.1713 people in the Taiyuan were investigated.We filter the patient of MCI in the survey;make the case-control study in same community(TAIYUAI).The same way was used to investigate the people in DATONG(1420)and to filter the MCI;we make case-case study between the two communities.SPSS11.0 software was adopted for statistical analysis.Results:1 The distribution of MCI:In cross-sectional investigation,the morbidity of MCI in Taiyuan is 5.43%.There are 44 men(5.26%)and 49 women(5.59%)in the 93MCIs.The morbidity of 60-65 years old is 3.18%,65-70 years old is 3.77%,70-75 years old is 6.18%,and 75-80 years old is 9.50%,80 years old and above all is 14.46%.The morbidity of illiterate is 8.03%,primary is 4.7%,and middle school is 4.04%,college and above all is 3.70%.The morbidity of worker is 4.47%,house worker is 6.39%,and occupation in others is 7.11%.The morbidity of marry is 3.61%,unmarried is 43.04%.The morbidity of 1000元and above all is 3.98%,500-1000元is 5.35%,200-500元is 5.97%,200元and the following is 6.33%.The score of ZHISHI is highest and the KONGJIANTUILI is lowest in the male, while in the female the ZHISHI is lowest and the DUANQISHIJUANJIYI is highest. The scores of ZHISHI,TUPIANPEILIAN are higher in the male while the SHUZIGUANGDU,DUANQISHIJUANJIYI are higher in the female.2 In case-control study,one-way analysis shows that education (OR=5.051,95%CI 2.041-12.470),marry(0R=0.523,95%CI0.277-0.988),inhabitancy (OR=2.161,95%CI 1.249-3.765),exercise(OR=0.277,95%CI 0.123-0.421),income (OR=2.561,95%CI 1.470-4.465),smoking(0R=0.383,95%CI 0.150-0.979),relate to MCI.In addition,education(0R=0.271,95%CI1.560-2.140),employment(OR= 1.712,95%CI 1.370-2.140),marry(0R=0.576,95%CI 0.305-0.962)and exercise (OR=0.205,95%CI 0.089-0.471)are possible risk factors of MCI in multiple-way analysis.3 Canonical correlation analysis show that there are positive correlation between the education and SUANSHU,TUPIANPAILIAN while a negative correlation between the old,marry,income and SUANSHU,TUPIANPAILIAN in the first pair of canonical variables.In the second pair education and SHUZIGUANGDU,MUKUAITU,KONGJIETUILI is positive correlation while marry,sex and TUPIANPAILIAN is negative correlation.4 In case-case study,ZHISHI (t=4.305,P=0.000),SUANSHU(t=2.454,P=0.016),TIANTU (t=2.419,P=0.018),DUANQISHIJUEJIYI(t=3.026,P=0.003)has statistical significance in the two zones.Conclusion:The risk factor of old people's cognition have age,sex,education,marry,inhabitancy,income,smoking,drinking,exercise. The people in male,older age,lower education,unmarried,living alone,lower income,smoking is easy to suffer from MCI.The expressions of cognition impression are different in the people,the man's score of ZHISHI quiz is highest while KONGJIETUILE is lowest;The women' s score of DUANQISHIJUEJIYI quiz is highest while ZHISHI is lowest.The comparison in the different sex show that the scores of ZHISHI,TUPIANPEILIAN are higher in the male while the SHUZIGUANGDU,DUANQISHIJUANJIYI are higher in the female.Canonical correlation analysis show that the scores of SHUSU,TUPIANPEILIAN,SHUZIGUANGDU,MUKUAITU,KONGJIETUILI are higher to the higher education,the score of TUPIANPEILIAN quiz is lower in the people who is old age,unmarried,lower income and in female.We intervening all the factors which can be intervened,there are important meaning in improving the life quality of old people;we can use different methods in the different zone.