| Objective: In order to research the distribution of TCM syndromes in sufferers with obstructive sleep apnea-related hypertension,and to explore the relevance between each of syndrome types and risk factors for example obesit,smoking,alcohol,etc.Methods: From December 2019 to January 2021,160 patients were enrolled and investigated in study selected sufferers,who met the OSAHS-related hypertension diagnostic criteria in the general medicine/gerontology clinic and hospitalization of Yan’an Hospital in Kunming.160 patients were 108 male and 52 female,an average age of(52.93±12.245)years;At the same time we need to record general information(height,weight,neck circumference,abdominal circumference,,history of smoking and drinking,etc.),and improve laboratory related indicators(FPG,2h PG,Hb A1 c,TC,TG,LDL-C,HDL-C,renin activity,aldosterone),sleep breathing monitoring and clinical observation tables,and perform TCM syndrome differentiation into sputum.We analyze the distribution of the four syndrome types,including dampness,phlegm and blood stasis,liver-fire hyperactivity,and yin and yang deficiency,and explore the relationship between each TCM syndrome type and risk factors.Results:1.The 160 patients with OSAHS-related hypertension were recorded into the group according to the TCM syndrome classification: 50 cases of phlegm and blood stasis(31.25%),44 cases of phlegm-dampness type(27.5%),37 cases of hyperactive liver and fire(23.15%),29 cases of yin and yang deficiency type(18.125%),of which phlegm and blood stasis were more common,and phlegm and dampness were more common,accounting for 58.75% of the total.2.There was no statistically significant difference in the composition ratios of hypertension combined with mild,moderate,and severe OSAHS and each syndrome type(P>0.05);Among them,the mild and severe groups were predominantly phlegm and blood stasis type,the moderate group was predominantly phlegm-dampness type.3.There were significant differences in drinking and smoking between different TCM syndrome types(P<0.01),and patients with congested phlegm-dampness type smoke and drink the most.4.There were differences in BMI,neck circumference,and abdominal circumference among different TCM syndrome types(P <0.05).Neck circumference,abdominal circumference,and BMI were maximum clinical indicators in patients with phlegm-dampness type.5.TC、TG differences between different TCM syndromes were statistically significant(P <0.05).The TG clinical indicators of patients with phlegm and dampness was the highest,and the TC clinical indicators of patients with phlegm and blood stasis was the highest;HDL-C,LDL-C differences between different TCM syndromes were not statistically significant,(P >0.05).6.The difference in glycosylated hemoglobin(Hb A1c)between different TCM syndrome types was statistically significant(P <0.05).The Hb A1 c clinical indicators of patients with Yin and Yang deficiency type was the highest;FPG between different TCM syndrome types,2h PG and FINS were not statistically significant(P>0.05).7.There were differences in renin activity between different TCM syndrome types(P <0.05).The renin activity value of patients with hyperactive liver fire was the highest;there was no not statistically significant between aldosterone and different TCM syndrome types,(P>0.05).8.Perform binary logistic regression analysis,TC,TG,LDL-C were risk factors for patients with hyperactive liver fire;TG,LDL-C,and aldosterone were risk factors for patients with phlegm and blood stasis;LDL-C,HDL-C,smoking and neck circumference were a risk factor for patients with phlegm and dampness;FPG,2h PG,HDL-C,LDL-C,body mass index,neck circumference,and smoking were risk factors for patients with yin and yang deficiency factors,(P <0.05).Conclusion:1.OSAHS-related high blood pressure patients were mainly classified into phlegm and blood stasis in traditional Chinese medicine,and phlegm and dampness in the main type(58.75%).2.Neck circumference,abdominal circumference,BMI,renin activity,TC,TG,Hb A1 c,smoking,drinking,and OSAHS-related hypertension have statistically significant differences among the four TCM syndromes;Among them,patients with congested phlegm-dampness type smoke and drink the most,neck circumference,abdominal circumference,BMI and TG were maximum clinical indicators;patients with phlegm and blood stasis have the highest TC;patients with yin and yang deficiency have the highest Hb A1c;patients with hyperactive liver and fire have the highest renin activity.There was no statistically significant difference in HDL-C,LDL-C,FPG,2h PG,and aldosterone among different TCM syndrome types.3.The risk factors of phlegm and blood stasis in patients with OSAHS-related hypertension were TG,LDL-C,and aldosterone;the risk factors of phlegm-dampness were HDL-C,LDL-C,smoking,and neck circumference;hyperactive liver-fire type The risk factors were TC,TG,LDL-C;the risk factors of yin and yang deficiency were FPG,2h PG,HDL-C,LDL-C,BMI,neck circumference,and smoking.Among them,LDL-C was a common risk factor for the four TCM syndromes in patients with OSAHS-related hypertension;TG was a common risk factor for phlegm and blood stasis and hyperactive liver fire;neck circumference,smoking,and HDL-C were the common risk factors for phlegm and dampness type and yin and yang deficiency type. |
