The Protective Effects Of Exogenous Leptin In Acute Pancreatitis Rats

Objective: To investgate exogenous leptin uses in acute pancreatitis (AP) rats, it can modulates the pro-inflammatory cytokine TNF-α,IL-1βand anti-inflammatory cytokine IL-4, protects the acute pancreatitis rats from damage induced by sodium taurocholate.Methods: AP rats were produced by 5% Sodium taurocholate, 10 minutes later, exogenous leptin was injected i.p. 6 hours later, measured serum amylase, leptin , cytokine TNF-α,IL-1βand cytokine IL-4 . Observing the changes of pathology of the pancreas.Results: In group which injected with exogenous leptin , the levels of serum amylase, cytokine TNF-αand IL-1βwere significantly reduced , the levels of serum leptin and cytokine IL-4 were significantly increased. Furthermore , the extent of necrosis of the pancreatic tissue was relieve.Conclution: (1) exogenous leptin protects the rats pancreas against damage by sodium taurocholate. (2) the protective effects of exogenous leptin are attributive to the reduction in cytokine TNF-α,IL-1βand to the increase in cytokine IL-4 production.