The Relation Between Serum Resistin, Adiponectin, Leptin In Patients With Essential Hypertension

Objective To explore the serum concentrations of resistin, leptin, insulin, bilirubin andadiponectin in patients with essential hypertension, and their functions duringoccurring and development of essential hypertension and obesity.Methods After blood pressure, body mass and height were measured routinely, andbody mass index(BMI)was caculated, eighty cases with essential hypertension andeighty-five healthy controle subjects which were measured off two subgroupsaccording to BMI, were taken fasting blood samples 5 mililiters for measurements ofbiochemistry, serum resistin, adiponectin, leptin and bilirubin etc.Results Compared with normal control, the two subgroups of hypertension havehigher concentrations of serum resistin [[(22.35±2.05)ug/L vs (25.15±1.77) ug/L,P＜0.001]and leptin; have lower concentrations of adiponectin and bilirubin; andhave higher concentrations of LDL[(4.24±0.52)ummol/L vs (2.68±0.43) ummol/L],moreover, the resistin(P=0.014)and leptin(P=0.041)leves of two subgroups havestatistical difference. Pearson relation analysis showed that resistin levels werepositively and significantly correlated with systolic blood pressure, median bloodpressure, insulin and LDL-C, while they were negtively and significantly correlatedwith adiponectin (r=-0.711). Multiple regression analysis showed thatLDL-C(B=1.258), insulin(B=0.785), adiponectin (B=-0.215)were resistin independentfactors in essential hypetension, and pearson relation analysis showed that bilirubinwas negtively and significantly correlated with LDL-C in the whole subjects.Conclusion The resistin, insulin and leptin concentrations were significant higherbut adiponectin lower in patients with essential hyertension, and there were positiveand significant correlation between them and blood pressure, so we may concoludethat they may participate in the incure and compentension of essential hypertension.There was significant correlation between the resistin, adiponectin and blood pressure, and the result suggested resisitin that might play regulative roles through LDL-C andadiponectin. in the development of hypertension. There was significant correlationbetween the bilirubin and essential hypertension, and the result suggested bilirubinmight play regulative roles through LDL-C in the development of hypertension.