A Study On The TCM Syndrome Classification And Mechanism Of Post-Stroke Fatigue

BackgroundStroke is characterized by its high incidence, fatality and disability rate.Tiredness is prevalent in patients with stroke, referred as Post-StrokeFatigue (PoSF) by documents. It reduces the consequence of stroke. Therefore,it is important to remove the tiredness and improve patient's sports tolerance.ObjectiveThe purpose of our study is①to explore the relationship between PoSFand its TCM syndromes,②to investigate the connection between the degreeof fatigue and its TCM syndromes,③to find out the main reasons and mechanismof PoSF,④to discover its influences on rehabilitation.⑤to establish arelation-model between the TCM syndromes of PoSF and clinical micro-index.The study is presumed to lay a foundation to reveaI the inner aspect of PoSFand to find out a solution way with the treatment of integrated TraditionalChinese and Weston Medicine.Methods200 hospitalized patients with a course of 15 days to 3 months wereincluded in the prospective study based on clinical manifestation andlaboratory examination. The patients were selected with 2 items -theeffectiveness on energy and emotions in SS-QQL. TCM syndrome differentiationwas carried out on National Stroke Diagnosis and Treatment Standard. In themorning of second hospitalization day, a blood test was done on itscorticosteroid, cardio-enzymes and interleulein-6 and other chemical index.These results were analyzed with SPSS 11.5 for statistical significances.Results1. Qi-insufficiency with blood stagnation and qi-insufficiency with blood stagnation/phlegm were the main syndromes of PoSF. The more serious degreeof PoSF was, the more frequent the two syndromes were.2. The degree of PoSF was correlated with blood corticosteroid and leucocyte(P=0.01＜0.05), without statistical significance with Interleukin-6,BUN,testosterone,CK,CK-MB,lactic acid dehydrogenase and hydroxybutyrate.3. Blood corticosteroid and BUN of different syndromes showed statisticalsignificances, no statistical differences were found in other laboratory indexas Interleukin-6,blood leucocyte,testosterone,CK,CK-MB,lactic aciddehydrogenase and hydroxybutyrate.DiscussionBlood testosterone was showed to be a reference parameter in the degreeof PoSF. Qi-insufficiency with blood stagnation and qi-insufficiency withblood stagnation/phlegm were the main syndromes of PoSF. Therefore, completingQi with promoting blood and dissipating phlegm are predominantly employed inthe treatment of PoSF in Traditional Chinese Medicine.