| Objects To explore the characteristics of cognitive function in patients withdepression.Method 143 patients with depression who are treated in the First AffiliatedHospital of Kunming Medical College during 2006 Jan～Dec were interviewedwith Verbal Fluency Test, Trail making test, WCST, Tower of Hanoi, MMPI, LES,HAMD, and HAMA for cognitive function testing. To explore the characteristicsof cognitive function in patients with depression though analyze the cognitivefunction with depression, anxiety, personality, life event, age and educationlevelResult 1. The finishing time of Trail making test A was positively correlatedwith the total score of HAMD, somatization, retardation and sleep disturbance.The finishing time of Trail making test B was positively correlated with the totalscore of HAMD, somatization, retardation, weight, cognitive disturbance andsleep disturbance. The right numbers of WCST was negatively correlated withthe total score of HAMD, somatization, retardation, weight. The errors ofWCST were positively correlated with the total score of HAMD, somatization,retardation, weight. The continuing errors of WCST were positively correlatedwith the total score of HAMD, somatization, retardation, weight and cognitivedisturbance. The uncontinuing errors of WCST was negatively correlated withcognitive disturbance. The total number of vocabulary fluency test wasnegatively correlated with the total score of HAMD and weight. The repeatednumber of vocabulary fluency test was positively correlated with somatization. The errors of vocabulary fluency test were positively correlated withsomatization. The average planning time of Hanoi tower were positivelycorrelated with sleep disturbance. The average performing time of Hanoi towerwere positively correlated with sleep disturbance. The total moving numbers ofHanoi was negatively correlated with the total score of HAMD, sleepdisturbance and retardation. The total score of Hanoi tower was negativelycorrelated with the total score of HAMD, sleep disturbance and retardation.2. Compare relapse depressive patients with first depressive patients, thereare difference in the taken time on Trail making test A, errors on Trail makingtest A, the times of letting the pen off the paper in trail making test B, totalnumber of vocabulary fluency test, the difference of average performing time ofHanoi tower, there is no significantly difference in WSCT testing betweenrelapse depressive patients with first depressive patients.3. The total score of HAMA was positively correlated with the finishing timeand the times of letting the pen off the paper of Trail making test A, the finishingtime and the times of letting the pen off the paper of Trail making test B, errors,errors and the continuing errors of WCST. And it is negatively correlated withthe right numbers of WCST, sort number, total score of Hanoi tower, and it isno correlated with vocabulary fluency test. We found that somatic anxiety ofHAMA was positively correlated with the finishing time and the times of lettingthe pen off the paper of Trail making test A, the finishing time and the times ofletting the pen off the paper and errors of Trail making test B, errors and thecontinuing errors of WCST, and it is negatively correlated with total score ofHanoi tower, it is no correlated with vocabulary fluency test.4. MMPI had no significant correlation with trail making test, vocabularyfluency test and WCST, but had correlation with Hanoi tower: the averageplanning time of Hanoi tower was positively correlated with Hy,Pd andnegatively correlated with Si. The average performing time was positivelycorrelated with Hy,Pd,Mf,Pt,Ma and negatively correlated with Pa,Si. Thetotal moving times was negatively correlated with Hy. The foul times was positively correlated with Hy,Pd,Pt,Ma and negatively correlated with Pa,Si. The total score was positively correlated with Pa,Si and negativelycorrelated with D,Hy,Pt,Sc.5. The total score of positive and negatively life events is positively correlatedwith errors of trail making test A, the total score of positive life events isnegatively correlated with total score of Hanoi tower.6. Finishing time of Trail making test A and B, the errors and continuing errorsof WCST, the total moving times of Hanoi tower were positively correlated withmarriage; right times and sorting numbers of WCST, the total scores of Hanoitower and the total number of the vocabulary fluency test were negativelycorrelated with age; the total scores of Hanoi tower and the times of letting thepen off the paper in trail making test A were negatively correlated withdepressed time.Conclusion 1. The severity of symptoms of depressive patients wascorrelated with the cognitive dysfunction, but the correlated is not simpleparallel relationship. 2. The first and relapse depressive patients both havefrontal cortex dysfunction, WCST testing, which is frontal cortex function andperforming function changing can not be the evidence to forecast depressorrelapsing or not, the relapsing of depressor will cause increasing of cognitivedysfunction of the depressive patients. 3. The severity of anxiety is negativelycorrelated with the cognitive function, but they are inconsistently in differenttesting objective. Psychic anxiety and somatic anxiety are correlated with thecognitive dysfunction. But though they have are correlated with the cognitivefunction, they are inconsistently in different testing objective. 4. Depressivepatients with psychopathic deviate or hysteria personality would play worse oncognitive function. Reversely, Depressive patients with social introversionpersonality would play better. 5. Both position and negatively life stimulation willcause the declining of cognitive function of depressor; the frontal cortexdysfunction of depressor, which we called performing dysfunction, is nocorrelated with life event. 6. The Cognitive dysfunction in patients with depression is correlated with gender, age, education, marriage, and notcorrelated with family history, stress life event of earlier, parents marriage,interpersonal relationship, working ability before sick.
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