Association Of Coronary Artery Calcification And Arterial Elastic Function

Objective: Coronary artery disease (CAD), which physiopathology basis is coronary artery atherosclerosis (CAA), is not only the main reason that harms people's health, but also the most serious cause of mortality. Now, coronary artery calcium score (CS) obtaining by multi-slice spiral CT (MSCT) is the best methods to detect coronary artery calcification (CAC) which is a high sensitive and specific sign of coronary atherosclerosis. Coronary artery calcium scores also revealed excellent correlation with selective coronary angiography (SCA) in detecting coronary atherosclerosis.The abnormal of arterial elastic function is one of the coronary artery disease risk factors, which affect coronary atherosclerosis through two mechanisms: increasing pulse pressure and endothelial dysfunction, calcification etc. Both coronary artery calcification and arterial elastic function can detect coronary atherosclerosis. As a non-invasive examination of arterial elasticity, C1 (large arterial elasticity index) and C2 ( small arterial elasticity index) have been considered the best parameter to reflect those changes on arterial endothelial dysfunction. The objective of this study is to explore the association of coronary calcium score and C1, C2, at the same time to determine the effect of coronary artery disease risk factors on calcium score and C1, C2.Method:The 16-slice spiral computed tomography and HDI-CV Profiler DO-2020 were performed for detecting calcium score (CS) and C1, C2 in 132 subjects including 46 patients with CHD, 52 patients with hypertension and 34 control subjects without disease. At the same time, Body mass index ( BMI ), systotic blood pressure (SBP), diastolic bloodpressure (DBP), pulse pressure (PP), pulse rate (PR) and mean pressure (MP) were measured. The patients were divided into two groups according to CS, CS≥300 in abnormal group, CS<300 in normal group.Result:1. C1 and C2 significantly decreased, but calcium score (CS) obviously increased with the increasing of age in CHD group, hypertension group and control group.2. CS in CHD and hypertension group presented obvious improving comparing with control group (P<0.01) in any years of age. C1 and C2 presented significant decreasing (P<0.05) in CHD group, but in hypertension group, C1 did not revealed statistical difference, but C2 revealed obvious decreasing (P<0.01) even in young group.3. CS in CHD group presented significant statistical difference, but C1 and C2 in CHD group did not presented difference comparing with hypertension group.4.CS was found having obvious negative correlation (P<0.01) with C1, C2, the coefficient of correlation were -0.102 and -0.322 respectively.5. C1, C2 presented obvious decreasing in CS≥300 group comparing with CS<300 group.Conclusion:1.CS and C1, C2 are two kinds of sensitive, non-invasive sign of early coronary atherosclerosis.2.Both CS and C1, C2 can demonstrate the damage of structure and function of arterial vascular wall which are caused by all kinds of coronary artery disease risk factors.3.Both CS and C1, C2 can serve as prognostic sign of early cardiovascular disease. CS reflect early abnormity of vascular structure, on the other hand, C1 and C2 reflect early abnormity of vascular function.4.CS and C1, C2 not only can prognose the development of cardiovascular disease, but also can point out the extent of cardiovascular damage.