A Pilot Study Of The Applyment Of Coronary Artery CTA To The Measurement Of Artery Elastic

Objective: To test 2 hypotheses: first, that coronary distensibility can be measured noninvasively using 64-slice computed tomographic angiography(CTA); and second, that the extent of coronary artery disease(CAD) in any individual patient is related to the degree of distensibility detected by CTA.Methods: We selected subjects from the author's work unit during January 2014 to June 2014. There were 30 subjects in the case group, they were reported to have moderate or severe stenosis by Computed tomographic angiography and diagnosed as CHD by coronary angiography examination, There were 30 subjects reported to be with no significant stenosis in the control group. All subjects were younger than 55 years. The main lesion located in the left anterior descending branch in patients with CAD. The cross-sectional coronary area of the left main and the left anterior descending arteries were measured in each phase(5%-95%, 10% each), and any change in the ratio was quantified. A distensibility value(D value) was determined for each artery.Result: Two CAD patients were excluded from the study because of motion artifacts. Thirteen patients had a diagnosis of single-vessel disease(LAD), nine patients had a diagnosis of 2-vessel disease, and eight patients had a diagnosis of 3-vessel disease. Compared to normal controls, the area change rate of the LAD artery in the patient group for the 65%, 75%, and 85% phases revealed significant differences(P<0.01). The area change rate of the LM artery for the 75% and 85% phases in the patient group also showed significant differences(P<0.01). The difference for the 65% phase was less marked(P>0.05). The coronary artery elastic have significant correlations with the degree of coronary artery stenosis and coronary heart disease, coronary calcification score and BMI of patients.Conclusion: Coronary artery distensibility can be measured noninvasively using data obtained from CTA. The distensibility of the coronary artery decreased with the increasing number of involved pathological coronary vessels. The distensibility of the coronary artery correlated with the extent of CAD. The coronary artery elastic have significant correlations with the degree of coronary artery stenosis and coronary heart disease, coronary calcification score and BMI of patients.