Analysis Of Pregnancy Outcome And Blood Glucose At Different Time Points In 75gOGTT

Objective: This study was to investigate the relationship between the blood glucose index of 75 g oral glucose tolerance test(75g OGTT)and pregnancy outcome at different time points,and to provide a theoretical basis for the stratified manage ment of maternal gestational diabetes.Methods: A total of 403 pregnant women who performed a 75 gOGTT at 24-28 g estational weeks received prenatal examination and delivered in the First Affiliated Hospital of China Medical University,from October,2012 to June 2016.Pregnant women were divided into three groups: group A was pregnant women with one abnormal blood glucose of 75 g OGTT result(group A1:fasting glucose abnormal;g roup A2:1 hour glucose abnormal;group A3:2 hour glucose abnormal),group B was pregnant women with two abnormal blood glucose of 75 gOGTT result(group B1:fasting glucose,1 hour glucose abnormal;group B2: fasting glucose,2 hour glucose abnormal;group B3: 1 hour glucose abnormal,2 hour glucose abnormal),and three abnormal blood glucose of 75 gOGTT result were in group C.Retrospective analysis of general information and pregnancy outcomes of pregnant women.Results: There was a significant difference between A,B and C groups of pregnant women with hypothyroidism,hypertensive disorders of pregnancy,cesarean section and newborns in body mass index,chest circumference,macrosomia,preterm birth,Neonatal Intensive Care Unit(P<0.05).The newborns in body mass index,chest circumference,fetal distress rate and pregnant women cesarean section rate of the A2 group were significantly higher than those of the A1 and A3 groups(P<0.05).The incidence of macrosomia and cesarean section in group B3 was lower than that in group B1 and B2(P<0.05).Conclusions: When three time blood glucose of 75 gOGTT are abnormal,the adverse outcomes would increase both in maternal and neonatal.When the blood glucose is abnormal after fasting glucose and 1 or 2 hour glucose abnormal,the incidence of neonatal macrosomia would increase.Compared with fasting glucose and 2 hour glucose abnormal,there is a good correlation between blood glucose and neonatal body mass index at 1 hour after 75 gOGTT.