The Foundational And Clinical Research Effection Of PGE1 Reversed DN

Diabetic Nephropathy(DN) is the capital chronicity Severity concurrent disease of diabetes and main etiopathogenisis of final stage nephropathy. If patients been findings and given utility treatment in time, protects and improve renal function in the initial stage of diabetic nephropathy, it's possible delay of reversed course of diabetic nephropathy. This research explores and analysises the influence and mechanism of PGE₁ works on the patients' renal function and nephridial tissue apoptotic in different stage ,by the methods of combine CR and empirical study, To summarize the opportunity and therapeutic regimen treat DN with PGE₁Empirical Study Objective: Probe the mechanism of PGE₁ in protecting DN kidney. Methods: Observe PGE₁ effected DN apoptotic and the expression of associated protein Fas and Fas-L. Result: post-treatment, the number fo DN apoptotic cells significant decrease, the expression of Fas and Fas-L down regulation. Conclusion: (1) PGE₁ can cut down DN blood ET-1 level, retrieve unbalancedness of PGI₂ / TXA₂, increase renal blood flow, lower vascular resistance, improve renal hemodynamics, degrade glomerulus internal pressure; (2)PGE₁ protects and improves renal function through repress immunoreactions ,decrease the activity and production of cell factor, mitigate Inflammatory reaction of kidney, accordingly reduce nephridial tissue apoptotic.Clinical Research Objective: To summarize the opportunity and therapeutic regimen treat DN with PGE₁. Methods: observe and treat on the selected the DN...