A Study On Relationship Between Childhood Asthma And Interaction Of Indoor Air Pollutants From Burning Coal And Genetic Polymorphisms Susceptible To Asthma

[Objectives] To take the measurements for indoor air pollutants from burning coal in Gui Ding, Gui Zhou province, including PM₄,SO₂,CO. Measurements were taken in asthmatic children's house. To detect 16, 27 locus of β₂-AR and ACE genetic polymorphisms. So as to find out the linkage between childhood asthma and interaction of indoor air pollutants from burning coal and genetic polymorphisms susceptible to asthma.[Methods] Basic informations and blood samples of asthmatic children were collected. PCR was used to detect 16, 27 locus of β₂-AR and ACE genetic polymorphisms. Measurements for PM₄,SO₂,CO were taken in county and country respectively. Genotype frequencies of three genetic polymorphisms were calculated. Using the epidemiologic method of case-only study, the interaction of indoor air pollutants from burning coal and genetic polymorphisms susceptible to asthma was analyzed.[Results] PM₄, SO₂ and CO concentrations of county are within common standards. PM₄, SO₂ concentrations of country are in excess of common standards for 67% and 61% respectively while CO concentration is within guideline. The frequencies of...