The Effects Of Indoor Environmental Exposures In Early Life On Childhood Asthma

Purpose: Through investigating children’s health status and the indoor environment in early life,based on the Life Course Theory,explore the influence of indoor environmental factors exposure on childhood asthma at different stages,and provide relevant policy recommendations for the early prevention of childhood asthma.Methods: In this study,children aged between four and a half to eight years old were selected from patients in the respiratory department of a tertiary hospital in Chengdu to conduct a questionnaire survey.After excluding samples that did not meet the research standards,the total number of children who were finally included in the analysis of this study was 1,799,The average age is 6.0±1.1 years old,of which children with asthma account for 31.80%.This article takes the Life Course Healthy Development model as the theoretical basis for research.First,the Logistic regression model was used to conduct a single variate analysis of indoor environmental factors that affect childhood asthma in the early life.Secondly,the early life is divided into three stages before pregnancy,during pregnancy and after the child is born.Three Logistic regression models are constructed and mixed variate are adjusted.The indoor environmental factors such as pet keeping,tobacco smoke exposure,moving and decoration are divided into stages.Multi-variate analysis was included in the regression model to test the effects of early indoor environmental exposure on childhood asthma.Finally,the Logistic regression model with interaction terms and post-mortem analysis were used to analyze the interaction effects between environmental exposure factors.Results: Single-variate Logistic regression results preliminarily screened indoor environmental factors related to childhood asthma.After adjusting for mixed variate,the results of multi-variate Logistic regression showed that the correlation between keeping cats and dogs at different stages of life and childhood asthma is not statistically significant.Early life fathers smoking more than 10 cigarettes a day will significantly increase the risk of children suffering from asthma.Among them,the level of significance is the highest at this stage after the child is born.Throughout the early stages of life,other people in the family smoking 1-10 cigarettes a day will also significantly increase the risk of asthma in children.The correlation between moving and interior decoration at different stages and the risk of childhood asthma is not statistically significant.Through further exploration of the interaction of simultaneous exposure to two environmental factors,it is found that on the basis of the additive model,the early father’s daily smoking number between 1-10 cigarettes may have an antagonistic effect on childhood asthma when they are at the same time.However,before and during pregnancy,there may be a synergistic effect on childhood asthma when the father smokes more than 10 cigarettes a day and keeping a dog at home.After the child is born,when the father smokes more than 10 cigarettes a day and keeping a dog at home,there may be an antagonistic effect on childhood asthma.On the basis of the multiplicative model,there may be negative multiplicative interactions during the entire early life when exposed to the environment where the dog is kept and the father smokes at the same time.In this study,due to the insufficient sample size,the statistical test of the interaction is not enough,so the interaction between the two needs to be further studied.Conclusion: In the living environment of Chinese cities,early life exposure to tobacco smoke is the main indoor environmental risk factor for childhood asthma;at the same time,there may be a certain interaction between keeping dog and father smoking on the risk of childhood asthma,which needs further research.Finally,provide relevant suggestions for the intervention of indoor environmental factors in early life and child health management.