Abnormal Expression Of Water Channel Proteins In Human's Nasal Polyps

Background:Nasal polyps is a common chronic inflammatory disease of nose and sinus. Morphologic features of nasal polyposis include proliferation and thickening of epithelium, glandular hyperplasia, angiogenesis, accumulation of extracellular matrix and areas of focal fibrosis. The pathophysiological mechanisms of the formation, growth and recurrence of nasal polyps remain poorly understand. Allergology,Multiple Factor Etiology and nasal airway resistance(NAR) are main inflammatory factors, which may play an important role in the formation and growth of nasal polyps.Aquaprins (Water Channel Proteins) are a group membrane proteins which penetrate water selectively. Wellner detected the AQP8 and then confirmed :most of the Aquaporins(AQP) existed as the intrinsic active state in their distributed constitutions. Generally they do not demand the"gating"or other adjustments. Thus the study on water metabolism is on a new stage. nasal polyp , the highly edematous constitution, the diluted tissue fluid, the decreased ion concentration , results in extracellular fluid to reduce . water passes by the water channel from tissue fluid to intracellular.