The Change Of Serum Resistin And Its Role In Acute Cerebral Infarction

Background: Resistin was discovered by Steppan in 2001. The discoveryderives from an effort to understand how a class of compounds known as thiazolidinediones (TZDs) can improve insulin sensitivity. Steppan found that following treatment of a mouse adipocyte clonal cell line (3T3-L1) with a TZD, some genes differentially expressed . A search for genes downregulated by TZDs led to the discovery of resistin.There is a tight link between resistin and obesity. In vitro, resistin can suppress conversion from 3T3-L1 cells to adipocyte. In vivo, Steppan demonstrated that obesity induced by a high-fat diet, mutation of the leptin gene, or mutation of the leptin receptor gene is associated with increased circulating resistin concentrations. Clinical trials showed that there was more resistin protein in both serum and adipose tissue in obese than in lean individuals, with a significant positive correlation between resistin and body mass index.Initial studies suggested that resistin had significant effects on insulin action, potentially linking obesity with insulin resistance and type 2 diabetes mellitus. In vitro , treatment of cultured 3T3-L1 with recombinant resistin impairs insulin-stimulated glucose uptake whereas anti-resistin antibodies prevent this effect .Similarly, in vivo, treatment with recombinant resistin in rodents induces insulin resistance,...