Expression Of CYR61,CTGF And WISP-1 In Human Lung Cancers And Effect Of SFN On CYR61

Lung cancer has been the leading cause of cancer death in the world. Moreover, increasing evidence has indicated the implication of CCN proteins in tumorgenesis, the up-regulated or down-regulated expression of CCN proteins have been widely observrerd in many kinds of cancers, implying their positive or negative regulations to different tumors. In human lung cancer cell lines, cysteine-rich protein 61(CYR 61) and connective . tissue growth factor (CTGF) had been demonstrated to inhibit the metastasis and invasion of cancer cells and were described as potential metastasis-supperssors. CYR61 acted as a tumor suppessor in the growth of non-small cell lung cancer (NSCLC) cells, and it suppressed the growth of NSCLC cells by triggering a signal transduction pathway through up-regulation of p53. WISP-1 and WISP-2 may play a role in down-regulating wnt-signaling. Sulforaphane (SFN) is an isothiocyanate isolated from cruciferous vegetable which is rich in vegetable-broccoli. SFN inhibits the development of carcinomas in mutiple stages which is also a potent cancer theraputic drug. The relationship between SFN and carcinoma is becoming the remarkable issue of oncology and nutriology.