1.ABCA1 Gene R219K Polymorphism: Its Influence On Serum Lipids And Its Association With Coronary Heart Disease And Type 2 Diabetes Mellitus 2.Rapid Detection Of InfluenzaA/B

Background and objectiveLow plasma high density lipoprotein cholestrol (HDL-C) is now generally accepted as a strong and independent risk factor for the development of premature atherosclerosis. HDL has a key role in reverse cholesterol transport (RCT), mobilizing cholesterol from the peripheral tissues to liver. In this process, the ATP-binding cassette transporter 1 (ABCA1) protein controls the efflux of intracellular cholesterol to apolipoprotein (apo) AI, the major apolipoprotein of HDL and is crucial for the initial steps. Since ABCA1 mutations were discovered to cause Tangier disease, a rare recessive hereditary disorder characterized by severe HDL deficiency, sterol deposition in macrophages and premature atherosclerosis, it has been speculated that common single nucleotide polymorphism(SNP) in ABCA1 might also contribute to antherosclerosis progress, coronary heart disease severity and variations in plasma HDL cholesterol levels in the general population. The G1051A polymorphism of exon 7 results in the substitution of a lysine for arginine at amino acid 219 of the ABCA1 protein. But reports on relationship between R219K polymorphism of ABCA1 gene and risk for coronary heart disease (CHD) are paradoxical abroad and are less at home.The study is to investigate the effects of R219K polymorphism of ABCA1 gene on blood lipids and its relationship with coronary and melitus diabetes in Han nationality, thus to provide scientific basis for atherosclerotic vascular disease.Subjects and methodBeing of Han nationality, all the subjects come from Northern China. It included 4...