Comparatire Study Of Three Prestriptions Composed Of Gualou Xiebai In Theory And Experiment For Treating Stagnation In Chest And Precordial Pain

Thoracic obstruction and heartache are the common diseases in clinic. The prescriptions of Snakegourd fruit and longstamen onion bulb are recorded by Synopsis of Golden Chamber. Snakegourd fruit, longstamen onion bulb and distillate spirit decoction, Three famous prescriptions such as Snakegourd fruit, longstamen onion bulb and pinellia tuber decoction, immature orange fruit, longstamen onion bulb and cassia twig decoction are often used in clinic for treating thoracic obstruction and heartache. From the view of ancient-modern document, the article summaries and elucidates their clinic application and compatibility feature. At the same time, for revealing the influences of different compatibility of three prescriptions on myocardial ischemia and oxygen deficiency from the view of experimentation, the experimentation as follows is developed.Methods: l.compare bearing anoxic's time of three prescriptions, apply mouse oxygen deficiency model under common depression caused by dichloroisopropyl carbamate.2.Apply intravenous injecting hypophysin under tongue to rat, resulting in acute myocardial ischemia modern, observing T-wave changing percentage of II lead electrocardiogram after injecting hypophysin and influence on LDH, CK, SOD, MDA contents. The consequence indicates: the prescriptions of Snakegourd fruit and longstamen onion bulb have the functions of prolonging mouse's survival time under common depression and hypoxia states , however, Snakegourd fruit, longstamen onion bulb and distillate spirit decoction and Snakegourd fruit, longstamen onion bulb and pinellia tuber decoction are better than immature orange fruit, longstamen onion bulb and cassia twig decoction, they have statistic meaning. In the experimentation of applying hypophysin intravenous injection under tongue leading to rat acute myocardial ischemia, result indicates three prescriptions have tendency anti- acute myocardial ischemia, the effect of immature orange fruit, longstamen onion bulb and cassia twig decoction is obvious. Three prescriptions have descending tendency considering the effect on LDH, CK. The function of immature orange fruit, longstamen onion bulb and cassia twig decoction is better than Snakegourd fruit, longstamen onion bulb and distillate spirit decoction and Snakegourd fruit, longstamen onion bulb and pinellia tuber decoction considering the effect on SOD, MDA. They have the statistic meaning.The results: the prescriptions of Snakegourd fruit and longstamen onion bulb have the functions of anti-oxygen deficiency and anti-acute myocardial ischemia, but anti-oxygen deficiency effect of Snakegourd fruit, longstamen onion bulb and distillate spirit decoction and Snakegourd fruit, longstamen onion bulb and pinellia tuber decoction is better than immature orange fruit, longstamen onion bulb and cassia twig decoction. And antioxidation effect of immature orange fruit, longstamen onion bulb and cassia twig decoction is better than Snakegourd fruit, longstamen onion bulb and distillate spirit decoction and Snakegourd fruit, longstamen onion bulb and pinellia tuber decoction.