Making Use Of The Histamine-skin-test Compared The Function Of Chinese Traditional Medicine And Western Medicine

Purpose: This research is a different and similar to make use of histamine-skin experiments to understand the Chinese herbal medicine antihistamine principle, contrast western medicine antihistamine function.Methods: Draft 40 patients of AR that according with the standard. Establish small-blue-dragon soup group(20), loratadine group (20). Observe the object take the small-blue-dragon soup , loratadine 10 mg. Histamine (20.1, 7.3 mmol/L) and mite (1: 100) skin tests were performed for each one before dosing and 7days after dosing. After 15 minutes measure wheal and flare areas, draw the AUDRC ( area under dose- response curve, AUDRC) , using trapezoid method calculation AUDRC for each subject, recorded and compared the data. All data were analysis in multivaraiate ANOVA.Result: l.The wheal and flare area compared with itself after dose and before dose There was no significantly differed in small-blue-dragon soup ( P>0. 05), in loratadine shows a highly significant treatment effecy( P<0. 05).2.The wheal and flare area of small-blue-dragon soup compared with the loratadine group No significantly differde in , loratadine before dose( P>0.05), no significantly differed in small-blue-dragon soup, the analysis of the loratadine and small-blue-dragon soup shows a highly significant treatment effect. ( P<0. 01)3.AUDRC The dose-response curves was no significantl differed in small-blue-dragon soup, loratadine before dose( P>0. 05). The AUDRC of loratadine compared with with small-blue-dragon soup shows significant. ( P<0. 05)4. Both the curative projects have distinctly curative effect. Compared withthe sympotoms before and after treatment, there is statistics distinguish(p<0. 05) .The small-blue-dragon group efficient is 58.82% and the lorata...