The Primary Study Of Mechanism Of Mifepriston On Early Medical Abortion

ObjectiveTo evaluate the possible mechanisms of the Mifepriston by investigating estrogen repectors(ER),progesterone receptors(PR) in villus and Tumor necrosis factor alpha(TNF-α),transforming growth factor-beta 1(TGF-β1) in decidua.Through this study to explore the possible mechanisms of bleeding long after medical abortion and provide a theoretical basis for fight against the deputy reaction of medical abortion.MethodsWe designed a study on seventy early pregnancy women ,all of them terminated pregnancy Voluntarly in The First Hospital of the Medical University between 2005.07 to 2005.10 .The experiment objects were divided into three groups on their owns accord.The study Group A(Group of mifepristone,n=30 ),the method is mifepristone 50mg on 10 AM,25mg on 10PM in the first day ,25mg on 10AM,25mg on 10PM in the second day ,25mg on 7 AM in the third day,and 8AM 600ug Misoprostol take orally, natural abortion after two to four hours and collect the samples. control group B(Group of induced abortion 1,n=20),200ug Misoprostol was placed in cunt on 8 AM on the induced abortion day,and operated after 2 hours.control group C(Group of induced abortion 2, n=20),without place Misoprostol before operate. Group B and C were operated on 10 AM,and collect the samples. Estrogen repectors(ER),progesterone receptors(PR) in villus and Tumor necrosis factor alpha(TNF-α) ,transforming growth factor-beta 1(TGF-β1) in deciduas were examined by immuno-...