Brain Injury Of Premature Infants And Analysis Of Risk Factor

Objective: To investigate the incidence of brain injury and risk factors in premature infants. Methods: 404 cases of hospitalized premature infants were conventional examined by the beside cranial ultrasound between 3 to 7 day after birth from Aug.2003 to Oct.2005. Results: Brain injury was diagnosed in 150 cases in premature infants. The mean gestational age of them was (33.27±1.99) weeks, and birthweight (1992.9±505.2) g. Total incidence of brain injury was 37.1%(150/404) , incidence of IVH and PVL were 35.2%(142/404) and 3.5%(14/404) respectively among all premature infants and the proportion of slight and severe brain injury were 23.5%(95/404) and 13.6%(55/404) respectively .The lower gestational age and birthweight, the higher the incidence of brain injury, but which was not correlated to degree of IVH. The incidence of complication, such as RDS, apnea, respiratory failure, pulmonary hemorrhage, hypoglycemia, multi-organ function failure and anemia was related to the degree of brain injury. Pregnancy-induced hypertension syndrome, asphyxia, intrauterin embarrassment, gestational age, birthweight and high-frequency oscillatory ventilation (HFOV) are the risk factor of brain injury in premature infants. Conclusion: The incidence and degree of brain injury in premature infants were related to many factors. We could early diagnose by cranial ultrasound and make it possible for us to intervene in and treat these patients as early as possible in order to prevent the bad prognosis.