Clinical And Experimental Research To Tonify Qi And Nourish Yin And Promote Blood To Restore Luo In The Treatment Of Unstable Angina

Objective:To investigate the clinical effects and mechanism of tonifing qi and nourishing yin and promoting blood to restore luo to treat unstable angina. Methods:For the clinical research, devided 63 patients into two groups, the Chinese herb group(32 patients) and the comparative group(31 patients),and treat them separately with Yixinshuluo Yin besides common west medicine and common west medicine.And study the clinical symptoms, ECG, blood pressure, blood lipid,hemorrheology and CD62p,CD63 and so on.For the experimental research,60 Wistar rats were made into myocardial ischemic models with epinephrine. And study the affections of Yixinshuluo Yin to ECG, SOD, MDA, ET, and TXB₂ of them. Results: Clinical investigations show that the Chinese herb group were improved more in clinical symptoms,signs, blood lipid level, blood pressure, blood thickness and platelet activity than the comparative group(P<0.01或P<0.01).Animale xperiental research show that acute myocardial rats were improved in ECG, MDA, ET, TXB₂, SOD.Conclusions: tonifing qi and nourishing yin and promoting blood to restore luo theropy can improve the endothelial function, relief coronary spasm, get rid of OFR and inhibit hyperoxidation of lipid, reduce blood thickness and platelet activity, so reliefathrosclerosis and prevent the formation of throbosis. So unstable angina is treated.