Effects Of Cilnidipine On Left Ventricular Midwall Mechanism, Haemodynamics During Isometric Exercise And RAS In Patients With Essential Hypertension

Background Hypertension has become a major disease suferring people's health, and is a serious public health problem in our society. So it is necessary to control blood pressure, especially drug therapy. Moreover, it is more important to reduce target organs dysfunction even to regress their pathological changes. Therefore patients' lifetime can be prolonged and the quality of life can be improved. Cilnidipine was first licensed to clinical use in 1995. Cilnidipine is a novel dihydropyridine calcium channel blocker (CCB), has potential inhibitory action on L-type as well as N-type calcium channels. In clinical trials cilnidipine was found to reduce blood pressure smoothly and lasting, it had less infuence on heart rate and the automic nervous system and caused less tachycardia than other dihydropyridine CCB, also cilnidipine can improve left ventricular diastolic function. However, it is unclear whether cilnidipine has effect on hemodynamics during isometric exercise, and whether cilnidipine can improve left ventricular systolic function.Objectives To evaluate effects of cilnidipine on the changes of hemodynamics and left ventricular diastolic function during isometric handgrip test to activate sympathetic nervous system. To determine whether there are demonstrable systolic function abormalities in patients with mild to moderate essential hypertension and to assess effects of cilnidipine on left ventricular systolic function by conventional systolic function measures and midwall fractional shortening (mFS). To assess effects...