The Relationship Among CT Appearances And Dynamic Enhancement With Tumor Angiogenesis And Proliferation Cell Nuclear Antigen Activity In Peripheral Lung Cancer

Objective:To study the relationship among CT appearances and dynamic enhancement with tumor angiogenesis , proliferation cell nuclear antigen(PCNA)expression and tumor malignant degree in peripheral lung cancer.Methods: Thirty patients with peripheral lung cancer (adenocarcinoma in 13 cases and squamous cell carcinoma in 12 cases other 5 cases)proved by surgery and pathology underwent enhancement dynamic CT scan before operation(pro-contrast and 20S,30S, 45S, 60S, 90S, 2min, 3min, 4min, 5min post-contrast), and the CT attenuations of the region of interest (ROI were measured. monoclonal antibody CD34and PCNA were expressed through immunohistochemical staining by means of SP methods.Results: MVD and PCNA value's carried no relation with the type of lung cancer ( P>0.05 ) . MVD and PCNA value's related with the degree of differentiation of the tumor cell and lesion's size, lobulation sign, spinous protuberance, vessel convergence sign,pleural retraction sign, lymph node metastasis (P<0.05) .though it showed no relation with spiculation sign ( P>0.05 ) .The mean enhanced CT values was(39.7385±10.07312) HU in adenocarcinomas,and (32.1667±9.95009 ) HU in squamous cell carcinomas. The CT values of both adenocarcinoma and squamous cell carcinoma had positive correlations to their corresponding MVD values(r=0.619 , P<0.05; r=0.586,P<0.05 ) .The degree of CT enhancement is not...