Studies On Molecular Mechanisms Of Yangyin Huoxue Decoction Delaying The Development Of Chronic Renal Failure

Transforming growth factorβis a series of polypeptide which adjusting growth and differentiation of cell. TGF-βhas many isomer, kidney more express TGF-β1. Some stimulating factor (for instance hyperproteinuria, HBP, hyperglycaemia ) urge renal tubular epithelial cell and interstitial vascular endothelial cell damage. TGF-β1 is increasing. TGF-β1 induce fibroblast proliferation . Collagen is increasing. ECM heavy cumulate in kidney. To cause interstitial fibrosis and glomcrulus hardening. At last to become CRF. CRF is a common end-resuid that continuity evolving various kinds kidney disease. To threaten straightly life of kidney patient. To study sign recently, There are close relationship between tubular interstitial lesion and CRF. In TIL, cell factor to lead to fibrosis is increasing. In it, TGF-β1 is a key cell factor that to participate nephric tubule and interstitial fibrosis. We had detected uric TGF-β1 of CRF patient. Meaning is to To explore the role and the changing regular of TGF-β1 in different phase of Chronic Renal Function Failure(CRF) and to approach its clinical significance. Our study in the treatment CRF patient were additionally treated with Yangyin Huoxue Decoction (YYHXD) based on western medicine. To overview the effection of the treaded group to serumal and urinary TGF-β1 and renal function. Methods The urinary levels of TGF-β1 were examined by ELISA method from 60 patients with CRF, as well as 16 health controls were examined. Sixty patients in CRF were randomly divided into treatment group and control group. Thirty cases in the control group were treated with low-protein diets, hypertension controlled and symptomatic treatment. Thirty cases in the treated group were additionally treated with YYHXD based on the control group. After one month to overview tow group effection and variation of renal function and changing of TGF-β1 blood serum and urine. Results The urinary levels of TGF-β1 from patients with CRF are higher than healthes. It step up gradually that the...