The Protection And Mechanism Of Anxingtongluotang On Focal Cerebral Ischemia-reperfusion Rats

Objective : Cerebral ischemia is a common disease in people. Morbidity has been rising progressively along with the increase of the aged people and the coming of senile society. The pathophysiological mechanism of cerebral ischemia disease is related with necrosis and delayed neuronal death after cerebral ischemia reperfusion. Thrombolysis, neuro-protective drugs (including glutamic acid antagonist, Ca2+ pathway blocker etc) and surgical treatment are applied ,but their protective effect is unsatisfactory. The new neuro-protective drugs are still in its experimental stage.Traditional Chinese medical theory think that blood stasis due to deficiency of Qi and Toxic materials in blood are the basic mechanism of cerebral ischemia reperfusion. Reinforcing genuine Qi, removing stagnation of blood and getting rid of pathogenic factors are important therapies for cerebral ischemia reperfusion in people.Some efforts have to be made before release of its pathophysiological mechanism and guide to protection of neurocyte and treat disease. The research is to study the mechanism of focal cerebral ischemia reperfusion rats and the protection and mechanism of danxingtongluotang on focal cerebral ischemia-reperfusion rats.In recent years, the analysis of LDH has already extensively applied in cell metabolism, organization dividing ,heredity and evolve etc. The LDH is one of important enzymes of energy metabolism in the cell and the...